TY - JOUR
T1 - Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes
T2 - A Danish Cohort Study
AU - Gedebjerg, Anne
AU - Bjerre, Mette
AU - Kjaergaard, Alisa Devedzic
AU - Steffensen, Rudi
AU - Nielsen, Jens Steen
AU - Rungby, Jørgen
AU - Friborg, Søren Gunnar
AU - Brandslund, Ivan
AU - Thiel, Steffen
AU - Beck-Nielsen, Henning
AU - Sørensen, Henrik Toft
AU - Hansen, Troels Krarup
AU - Thomsen, Reimar Wernich
N1 - © 2020 by the American Diabetes Association.
PY - 2020/9
Y1 - 2020/9
N2 - OBJECTIVE: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the association between MBL and the risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.RESEARCH DESIGN AND METHODS: In a cohort study of 7,588 patients with type 2 diabetes, we measured serum MBL in 7,305 patients and performed MBL expression genotyping in 3,043 patients. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses.RESULTS: Serum MBL and CVE showed a U-shaped association. Compared with the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI, 1.34-2.46) for the low-MBL category and 1.48 (95% CI, 1.14-1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared with the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI, 0.87-2.25) for the low-expression genotype and 1.44 (95% CI, 1.01-2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality.CONCLUSIONS: Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for CVD in this population.
AB - OBJECTIVE: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the association between MBL and the risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.RESEARCH DESIGN AND METHODS: In a cohort study of 7,588 patients with type 2 diabetes, we measured serum MBL in 7,305 patients and performed MBL expression genotyping in 3,043 patients. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses.RESULTS: Serum MBL and CVE showed a U-shaped association. Compared with the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI, 1.34-2.46) for the low-MBL category and 1.48 (95% CI, 1.14-1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared with the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI, 0.87-2.25) for the low-expression genotype and 1.44 (95% CI, 1.01-2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality.CONCLUSIONS: Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for CVD in this population.
UR - http://www.scopus.com/inward/record.url?scp=85090093829&partnerID=8YFLogxK
U2 - 10.2337/dc20-0345
DO - 10.2337/dc20-0345
M3 - Journal article
C2 - 32616614
SN - 0149-5992
VL - 43
SP - 2190
EP - 2198
JO - Diabetes Care
JF - Diabetes Care
IS - 9
ER -