Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease

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n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. The majority of previous studies investigating intake of marine- and plant-based n-3 PUFA have focused on CHD while other ASCVD such as ischaemic stroke and peripheral artery disease have been less studied. However, recent data from Danish Diet, Cancer and Health cohort suggest that marine n-3 PUFA may be inversely associated with risk of myocardial infarction, ischaemic stroke and peripheral arterial disease caused by atherosclerosis. The effect of the plant-derived n-3 PUFA α-linolenic acid on ASCVD is less clear and several gaps in the literature remain to be explored.

Original languageEnglish
JournalProceedings of the Nutrition Society
Issue number1
Pages (from-to)22-29
Number of pages8
Publication statusPublished - Feb 2020
EventNutrition Society Winter Meeting 2018: Optimal diet and lifestyle strategies for the management of cardio-metabolic risk - London, United Kingdom
Duration: 4 Dec 20185 Dec 2018


ConferenceNutrition Society Winter Meeting 2018
Country/TerritoryUnited Kingdom


  • Atherosclerotic cardiovascular disease
  • DHA
  • EPA
  • α-linolenic acid


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