Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

W Aasebø; M Svensson; T Jenssen; I A Eide

doi:10.1016/j.transproceed.2019.01.067

Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

W Aasebø^*, M Svensson, T Jenssen, I A Eide

^*Corresponding author for this work

Research output: Contribution to journal › Conference article in Journal › Research › peer-review

2 Citations (Scopus)

Abstract

UNLABELLED: Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.

METHODS: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.

RESULTS: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).

CONCLUSION: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.

Original language	English
Journal	Transplantation Proceedings
Volume	51
Issue number	2
Pages (from-to)	466-469
Number of pages	4
ISSN	0041-1345
DOIs	https://doi.org/10.1016/j.transproceed.2019.01.067
Publication status	Published - Mar 2019
Externally published	Yes
Event	29th Congress of the Scandinavian Transplantation Society - , Estonia Duration: 2 May 2018 → 4 May 2018 http://10.1016/j.transproceed.2019.01.082

Conference

Conference	29th Congress of the Scandinavian Transplantation Society
Country/Territory	Estonia
Period	02/05/2018 → 04/05/2018
Internet address	http://10.1016/j.transproceed.2019.01.082

Bibliographical note

Keywords

Adult
Aged
Dietary Supplements
Fatty Acids, Omega-3/administration & dosage
Female
Humans
Kidney Transplantation/psychology
Male
Middle Aged
Quality of Life
Surveys and Questionnaires
Transplant Recipients/psychology

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10.1016/j.transproceed.2019.01.067

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Cite this

@inproceedings{16631ec3e40e4472ae04c924d993c53b,

title = "Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant",

abstract = "UNLABELLED: Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.METHODS: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.RESULTS: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).CONCLUSION: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.",

keywords = "Adult, Aged, Dietary Supplements, Fatty Acids, Omega-3/administration & dosage, Female, Humans, Kidney Transplantation/psychology, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Transplant Recipients/psychology",

author = "W Aaseb{\o} and M Svensson and T Jenssen and Eide, {I A}",

note = "Copyright {\textcopyright} 2019. Published by Elsevier Inc.; 29th Congress of the Scandinavian Transplantation Society ; Conference date: 02-05-2018 Through 04-05-2018",

year = "2019",

month = mar,

doi = "10.1016/j.transproceed.2019.01.067",

language = "English",

volume = "51",

pages = "466--469",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier",

number = "2",

url = "http://10.1016/j.transproceed.2019.01.082",

}

TY - GEN

T1 - Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

AU - Aasebø, W

AU - Svensson, M

AU - Jenssen, T

AU - Eide, I A

PY - 2019/3

Y1 - 2019/3

N2 - UNLABELLED: Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.METHODS: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.RESULTS: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).CONCLUSION: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.

AB - UNLABELLED: Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.METHODS: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.RESULTS: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).CONCLUSION: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.

KW - Adult

KW - Aged

KW - Dietary Supplements

KW - Fatty Acids, Omega-3/administration & dosage

KW - Female

KW - Humans

KW - Kidney Transplantation/psychology

KW - Male

KW - Middle Aged

KW - Quality of Life

KW - Surveys and Questionnaires

KW - Transplant Recipients/psychology

U2 - 10.1016/j.transproceed.2019.01.067

DO - 10.1016/j.transproceed.2019.01.067

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C2 - 30879569

SN - 0041-1345

VL - 51

SP - 466

EP - 469

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 2

T2 - 29th Congress of the Scandinavian Transplantation Society

Y2 - 2 May 2018 through 4 May 2018

ER -

Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

Abstract

Conference

Bibliographical note

Keywords

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