Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies

Gunnar Lauge Nielsen, Claus Dethlefsen, Margrethe Møller, Henrik Toft Sørensen

Research output: Contribution to conference without publisher/journalPosterResearch

Abstract

Aim: To assess the association between maternal glycosylated haemoglobin (HbA1c) in diabetic pregnancies and the risk of delivering large for gestational age babies (LGA) taking into account maternal body mass index (BMI), weight gain, age, White class, and smoking habits.  Method: We identified all pregnant diabetic women in a Danish county. HbA1c values after 20th gestational week were collected and offspring was categorized as large, normal or small for gestational age. Logistic regression models we fitted to assess the association between HbA1c and risk of delivering a LGA baby taking into account the impact of potential confounding from the above mentioned factors.   Results: We found 209 singleton pregnancies of which 59% (95% CI: 52%-65%) terminated with a LGA baby. HbA1c, BMI, and weight gain were all associated with increasing risk of delivering a LGA baby. Analyses stratified on maternal BMI disclosed that the association was restricted to pregnancies with a pre-pregnancy BMI >23 kg/m2 below that we found no association.  Conclusion: The association between glycosylated haemoglobin and birth of a LGA baby seems to be restricted to women with BMI >23 kg/m2.
Original languageEnglish
Publication date2007
Number of pages1
Publication statusPublished - 2007
EventInternational Symposium on Diabetes and Pregnancy - Instanbul, Turkey
Duration: 29 Mar 200731 Mar 2007
Conference number: 4

Conference

ConferenceInternational Symposium on Diabetes and Pregnancy
Number4
CountryTurkey
CityInstanbul
Period29/03/200731/03/2007

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Gestational Age
Mothers
Body Mass Index
Weights and Measures
Pregnancy
Glycosylated Hemoglobin A
Weight Gain
Logistic Models
Pregnancy in Diabetics
Habits
Pregnant Women
Smoking
Parturition

Cite this

Nielsen, G. L., Dethlefsen, C., Møller, M., & Sørensen, H. T. (2007). Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies. Poster session presented at International Symposium on Diabetes and Pregnancy, Instanbul, Turkey.
Nielsen, Gunnar Lauge ; Dethlefsen, Claus ; Møller, Margrethe ; Sørensen, Henrik Toft. / Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies. Poster session presented at International Symposium on Diabetes and Pregnancy, Instanbul, Turkey.1 p.
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abstract = "Aim: To assess the association between maternal glycosylated haemoglobin (HbA1c) in diabetic pregnancies and the risk of delivering large for gestational age babies (LGA) taking into account maternal body mass index (BMI), weight gain, age, White class, and smoking habits.  Method: We identified all pregnant diabetic women in a Danish county. HbA1c values after 20th gestational week were collected and offspring was categorized as large, normal or small for gestational age. Logistic regression models we fitted to assess the association between HbA1c and risk of delivering a LGA baby taking into account the impact of potential confounding from the above mentioned factors.   Results: We found 209 singleton pregnancies of which 59{\%} (95{\%} CI: 52{\%}-65{\%}) terminated with a LGA baby. HbA1c, BMI, and weight gain were all associated with increasing risk of delivering a LGA baby. Analyses stratified on maternal BMI disclosed that the association was restricted to pregnancies with a pre-pregnancy BMI >23 kg/m2 below that we found no association.  Conclusion: The association between glycosylated haemoglobin and birth of a LGA baby seems to be restricted to women with BMI >23 kg/m2.",
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Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies. / Nielsen, Gunnar Lauge; Dethlefsen, Claus; Møller, Margrethe; Sørensen, Henrik Toft.

2007. Poster session presented at International Symposium on Diabetes and Pregnancy, Instanbul, Turkey.

Research output: Contribution to conference without publisher/journalPosterResearch

TY - CONF

T1 - Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies

AU - Nielsen, Gunnar Lauge

AU - Dethlefsen, Claus

AU - Møller, Margrethe

AU - Sørensen, Henrik Toft

PY - 2007

Y1 - 2007

N2 - Aim: To assess the association between maternal glycosylated haemoglobin (HbA1c) in diabetic pregnancies and the risk of delivering large for gestational age babies (LGA) taking into account maternal body mass index (BMI), weight gain, age, White class, and smoking habits.  Method: We identified all pregnant diabetic women in a Danish county. HbA1c values after 20th gestational week were collected and offspring was categorized as large, normal or small for gestational age. Logistic regression models we fitted to assess the association between HbA1c and risk of delivering a LGA baby taking into account the impact of potential confounding from the above mentioned factors.   Results: We found 209 singleton pregnancies of which 59% (95% CI: 52%-65%) terminated with a LGA baby. HbA1c, BMI, and weight gain were all associated with increasing risk of delivering a LGA baby. Analyses stratified on maternal BMI disclosed that the association was restricted to pregnancies with a pre-pregnancy BMI >23 kg/m2 below that we found no association.  Conclusion: The association between glycosylated haemoglobin and birth of a LGA baby seems to be restricted to women with BMI >23 kg/m2.

AB - Aim: To assess the association between maternal glycosylated haemoglobin (HbA1c) in diabetic pregnancies and the risk of delivering large for gestational age babies (LGA) taking into account maternal body mass index (BMI), weight gain, age, White class, and smoking habits.  Method: We identified all pregnant diabetic women in a Danish county. HbA1c values after 20th gestational week were collected and offspring was categorized as large, normal or small for gestational age. Logistic regression models we fitted to assess the association between HbA1c and risk of delivering a LGA baby taking into account the impact of potential confounding from the above mentioned factors.   Results: We found 209 singleton pregnancies of which 59% (95% CI: 52%-65%) terminated with a LGA baby. HbA1c, BMI, and weight gain were all associated with increasing risk of delivering a LGA baby. Analyses stratified on maternal BMI disclosed that the association was restricted to pregnancies with a pre-pregnancy BMI >23 kg/m2 below that we found no association.  Conclusion: The association between glycosylated haemoglobin and birth of a LGA baby seems to be restricted to women with BMI >23 kg/m2.

M3 - Poster

ER -

Nielsen GL, Dethlefsen C, Møller M, Sørensen HT. Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies. 2007. Poster session presented at International Symposium on Diabetes and Pregnancy, Instanbul, Turkey.