Measuring the administered dose of particles on the facial mucosa of a realistic human model

Mengjie Duan, Li Liu, Guillaume Da, Evelyne Géhin, Peter V Nielsen, Ulla M Weinreich, Borong Lin, Yi Wang, Ting Zhang, Wei Sun

Research output: Contribution to journalJournal articleResearchpeer-review

11 Citations (Scopus)
74 Downloads (Pure)

Abstract

Exposure to particulate contaminants can cause serious adverse health effects. Deposition on the facial mucosa is an important path of exposure, but it is difficult to conduct direct dose measurement on real human subjects. In this study, we propose an in vitro method to assess the administered doses of micron-sized particles on the eyes and lips in which computed tomographic scanning and three-dimensional printing were used to create a model that includes a face, oropharynx, trachea, the first five generations of bronchi, and lung volume. This realistic model of a face and airway was exposed to monodispersed fluorescent particles released from an incoming jet. The administered dose of particles deposited upon the eyes and lips, as quantified by fluorescence intensity, was determined via a standard wiping protocol. The results show that, in this scenario, the administered doses normalized by source were 2.15%, 1.02%, 0.88%, 2.13%, and 1.55% for 0.6-, 1.0-, 2.0-, 3.0-, and 5.0-µm particles, respectively. The administered dose of large particles on the mucosa within a given exposure time has great significance. Moreover, the lips suffer a much greater risk of exposure than the eyes and account for more than 80% of total facial mucosa deposition. Our study provides a fast and economical method to assess the administered dose on the facial mucosa on an individual basis.

Original languageEnglish
JournalIndoor Air
Volume30
Issue number1
Pages (from-to)108-116
ISSN0905-6947
DOIs
Publication statusPublished - Jan 2020

Bibliographical note

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords

  • 3D printing
  • CT scanning
  • Deposition
  • In vitro
  • Mucosal exposure
  • Occupational health
  • corona
  • corona virus
  • COVID-19

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