Aspergillus is a widely distributed fungal genus with great medical and commercial influence and with a high degree of metabolic diversity and complexity. Some species are known to cause infections in humans and animals, others produce harmful mycotoxins in food products, and many species are used industrially in food fermentation or for production of enzymes and biochemicals. In recent years, the newly developed CRISPR-Cas9 system has been recognized as a novel potent approach for precise genome editing in Aspergillus, which now powers fundamental research in physiology and genetics of aspergilli and greatly facilitates strain engineering for industrial applications. This Special Issue will collect original research and review papers covering the application of CRISPR-based systems in metabolic engineering of Aspergillus within all areas ranging from fundamental physiology and genetics studies to applied aspects, as well as optimization of the CRISPR-based systems.
| Publisher | MDPI |
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| Publication status | Published - 2022 |
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