MicroRNAs in Cancer and Cardiovascular Disease

Mirolyuba Ilieva, Riccardo Panella, Shizuka Uchida*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Although cardiac tumor formation is rare, accumulating evidence suggests that the two leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of pathogenesis, including angiogenesis, immune responses, and fibrosis. These similarities have led to the creation of new exciting field of study called cardio-oncology. Here, we review the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). As miRNAs are well-known regulators of translation by binding to the 3′-untranslated regions (UTRs) of messenger RNAs (mRNAs), we carefully dissect how a specific set of miRNAs are both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs). Furthermore, from the standpoint of similar pathogenesis, miRNAs categories related to the similar pathogenesis are discussed; namely, angiomiRs, Immune-miRs, and fibromiRs.
Original languageEnglish
Article number3551
Issue number22
Publication statusPublished - 10 Nov 2022


  • cancer
  • cardiovascular disease
  • miRNA
  • Heart
  • Cardiovascular Diseases/genetics
  • Humans
  • MicroRNAs/metabolism
  • Neoplasms/genetics
  • RNA, Messenger


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