Mitochondrial mutation m.3243a>g associates with insulin resistance in non-diabetic carriers

Jakob Høgild Langdahl*, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde, Per Heden Andersen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)
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Abstract

Aim: This case–control study aimed to examine impairments in glucose metabolism in non-diabetic carriers of the mitochondrial mutation m.3243A>G by evaluating insulin secretion capacity and sensitivity. Methods: Glucose metabolism was investigated in 23 non-diabetic m.3243A>G carriers and age-, sex-and BMI-matched healthy controls with an extended 4-h oral glucose tolerance test (OGTT). Insulin sensitivity index and acute insulin response were estimated on the basis of the OGTT. This was accompanied by examination of body composition by dual-energy X-ray absorptiometry (DXA), maximum aerobic capacity and a Recent Physical Activity Questionnaire (RPAQ). Results: Fasting p-glucose, s-insulin and s-c-peptide levels did not differ between m.3243A>G carriers and controls. Insulin sensitivity index (BIGTT-S1) was significantly lower in the m.3243A>G carriers, but there was no difference in the acute insulin response between groups. P-lactate levels were higher in carriers throughout the OGTT. VO2max, but not BMI, waist and hip circumferences, lean and fat body mass%, MET or grip strength, was lower in mutation carriers. BIGTT-S1 remained lower in mutation carriers after adjustment for multiple confounding factors including VO2max in regression analyses. Conclusions: Glucose metabolism in m.3243A>G carriers was characterized by reduced insulin sensitivity, which could represent the earliest phase in the pathogenesis of m.3243A>G-associated diabetes.

Original languageEnglish
JournalEndocrine Connections
Volume8
Issue number7
Pages (from-to)829-837
Number of pages9
ISSN2049-3614
DOIs
Publication statusPublished - Jul 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The authors Published by Bioscientifica Ltd.

Keywords

  • Insulin resistance
  • Mitochondrial DNA point mutation m.3243A>G
  • Mitochondrial dysfunction
  • Monogenic diabetes

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