Moderate mitral regurgitation in patients undergoing CABG - the MoMIC trial

Per Wierup, Henrik Egeblad, Sten Lyager Nielsen, Henrik Scherstén, Per-Ola Kimblad, Odd Bech-Hansen, Anders Roijer, Folke Nilsson, Patrick M McCarthy, Denis Bouchard, Jacob Jacobsen, Søren Paaske Johnsen, Steen Hvitfeldt Poulsen, Henning Mølgaard, MoMIC Trial Investigators

Research output: Contribution to journalJournal articleResearchpeer-review

7 Citations (Scopus)


BACKGROUND: The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial.

STUDY DESIGN: The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008.

IMPLICATION: If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.

Original languageEnglish
JournalScandinavian Cardiovascular Journal
Issue number1
Pages (from-to)50-6
Number of pages7
Publication statusPublished - Feb 2009
Externally publishedYes


  • Blood Vessel Prosthesis Implantation
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Heart Failure
  • Hospitalization
  • Humans
  • Mitral Valve Insufficiency
  • Myocardial Ischemia
  • North America
  • Research Design
  • Scandinavia
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome


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