Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study

S A J Schmidt; G V Sørensen; E Horváth-Puhó; L Pedersen; N Obel; K L Petersen; H C Schønheyder; H T Sørensen

doi:10.1038/bjc.2015.136

Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study

S A J Schmidt, G V Sørensen, E Horváth-Puhó, L Pedersen, N Obel, K L Petersen, H C Schønheyder, H T Sørensen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BACKGROUND: Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.

METHODS: By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.

RESULTS: Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.

CONCLUSIONS: Overall, HZ was not a predictor of increased mortality following subsequent cancer.British Journal of Cancer advance online publication 16 April 2015. doi:10.1038/bjc.2015.136 www.bjcancer.com.

Original language	English
Journal	British Journal of Cancer
Volume	112
Issue number	11
Pages (from-to)	1822-1826
Number of pages	5
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2015.136
Publication status	Published - 2015

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@article{5590289ca3ad4bb88ff26f2ef6c4138b,

title = "Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study",

abstract = "BACKGROUND: Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.METHODS: By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.RESULTS: Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.CONCLUSIONS: Overall, HZ was not a predictor of increased mortality following subsequent cancer.British Journal of Cancer advance online publication 16 April 2015. doi:10.1038/bjc.2015.136 www.bjcancer.com.",

author = "Schmidt, {S A J} and S{\o}rensen, {G V} and E Horv{\'a}th-Puh{\'o} and L Pedersen and N Obel and Petersen, {K L} and Sch{\o}nheyder, {H C} and S{\o}rensen, {H T}",

year = "2015",

doi = "10.1038/bjc.2015.136",

language = "English",

volume = "112",

pages = "1822--1826",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting

T2 - a nationwide cohort study

AU - Schmidt, S A J

AU - Sørensen, G V

AU - Horváth-Puhó, E

AU - Pedersen, L

AU - Obel, N

AU - Petersen, K L

AU - Schønheyder, H C

AU - Sørensen, H T

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.METHODS: By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.RESULTS: Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.CONCLUSIONS: Overall, HZ was not a predictor of increased mortality following subsequent cancer.British Journal of Cancer advance online publication 16 April 2015. doi:10.1038/bjc.2015.136 www.bjcancer.com.

AB - BACKGROUND: Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.METHODS: By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.RESULTS: Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.CONCLUSIONS: Overall, HZ was not a predictor of increased mortality following subsequent cancer.British Journal of Cancer advance online publication 16 April 2015. doi:10.1038/bjc.2015.136 www.bjcancer.com.

U2 - 10.1038/bjc.2015.136

DO - 10.1038/bjc.2015.136

M3 - Journal article

C2 - 25880013

SN - 0007-0920

VL - 112

SP - 1822

EP - 1826

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study

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