Mutation Rates of STR Systems in Danes

Kim Emil Andersen, Susanne Gammelgaard Bøttcher, Susanne Christensen, Poul Svante Eriksen, Malene Højbjerre, C. Hallenberg, B. Simonsen, N. Morling

Research output: Contribution to conference without publisher/journalPosterResearch

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Abstract

Danish paternity cases in the period 1999 to 2005 were investigated regarding mutation rates in STR loci. STR-typing was performed by the Applied Biosystems AmplfStr Profiler Plus kit in the period 1999 to early 2005, hereafter named the PP9, and by Applied Biosystems AmplfStr Identifier kit for the rest of 2005, hereafter named the IDFL. All cases with one to four genetic inconsistencies were manually inspected by two forensic geneticists and statistically analyzed by five statisticians. We found no significant effect of kits and no interaction of kits and STRA loci, but differences in mutation rates on different STR loci. In the cases where mutations had occured, we found no interaction between kits, STRA loci or sexes. However, we found differences in the mutation rates between the sexes, meaning that the differences in male and female mutation rates can be assumed constant over STR loci and kits. Sex and STR locus specific mutation rates were estimated with 95% confidence limits by the method of Clopper and Pearson (1934).
Original languageEnglish
Publication date2007
Publication statusPublished - 2007
EventInternational Society for Forensic Genetics (ISFG) Congress - Copenhagen, Denmark
Duration: 21 Aug 200725 Aug 2007
Conference number: 22

Conference

ConferenceInternational Society for Forensic Genetics (ISFG) Congress
Number22
CountryDenmark
CityCopenhagen
Period21/08/200725/08/2007

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Mutation Rate
Sex Characteristics
Mutation

Cite this

Andersen, K. E., Bøttcher, S. G., Christensen, S., Eriksen, P. S., Højbjerre, M., Hallenberg, C., ... Morling, N. (2007). Mutation Rates of STR Systems in Danes. Poster session presented at International Society for Forensic Genetics (ISFG) Congress, Copenhagen, Denmark.
Andersen, Kim Emil ; Bøttcher, Susanne Gammelgaard ; Christensen, Susanne ; Eriksen, Poul Svante ; Højbjerre, Malene ; Hallenberg, C. ; Simonsen, B. ; Morling, N. / Mutation Rates of STR Systems in Danes. Poster session presented at International Society for Forensic Genetics (ISFG) Congress, Copenhagen, Denmark.
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title = "Mutation Rates of STR Systems in Danes",
abstract = "Danish paternity cases in the period 1999 to 2005 were investigated regarding mutation rates in STR loci. STR-typing was performed by the Applied Biosystems AmplfStr Profiler Plus kit in the period 1999 to early 2005, hereafter named the PP9, and by Applied Biosystems AmplfStr Identifier kit for the rest of 2005, hereafter named the IDFL. All cases with one to four genetic inconsistencies were manually inspected by two forensic geneticists and statistically analyzed by five statisticians. We found no significant effect of kits and no interaction of kits and STRA loci, but differences in mutation rates on different STR loci. In the cases where mutations had occured, we found no interaction between kits, STRA loci or sexes. However, we found differences in the mutation rates between the sexes, meaning that the differences in male and female mutation rates can be assumed constant over STR loci and kits. Sex and STR locus specific mutation rates were estimated with 95{\%} confidence limits by the method of Clopper and Pearson (1934).",
author = "Andersen, {Kim Emil} and B{\o}ttcher, {Susanne Gammelgaard} and Susanne Christensen and Eriksen, {Poul Svante} and Malene H{\o}jbjerre and C. Hallenberg and B. Simonsen and N. Morling",
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Andersen, KE, Bøttcher, SG, Christensen, S, Eriksen, PS, Højbjerre, M, Hallenberg, C, Simonsen, B & Morling, N 2007, 'Mutation Rates of STR Systems in Danes', Copenhagen, Denmark, 21/08/2007 - 25/08/2007, .

Mutation Rates of STR Systems in Danes. / Andersen, Kim Emil; Bøttcher, Susanne Gammelgaard; Christensen, Susanne; Eriksen, Poul Svante; Højbjerre, Malene; Hallenberg, C.; Simonsen, B.; Morling, N.

2007. Poster session presented at International Society for Forensic Genetics (ISFG) Congress, Copenhagen, Denmark.

Research output: Contribution to conference without publisher/journalPosterResearch

TY - CONF

T1 - Mutation Rates of STR Systems in Danes

AU - Andersen, Kim Emil

AU - Bøttcher, Susanne Gammelgaard

AU - Christensen, Susanne

AU - Eriksen, Poul Svante

AU - Højbjerre, Malene

AU - Hallenberg, C.

AU - Simonsen, B.

AU - Morling, N.

PY - 2007

Y1 - 2007

N2 - Danish paternity cases in the period 1999 to 2005 were investigated regarding mutation rates in STR loci. STR-typing was performed by the Applied Biosystems AmplfStr Profiler Plus kit in the period 1999 to early 2005, hereafter named the PP9, and by Applied Biosystems AmplfStr Identifier kit for the rest of 2005, hereafter named the IDFL. All cases with one to four genetic inconsistencies were manually inspected by two forensic geneticists and statistically analyzed by five statisticians. We found no significant effect of kits and no interaction of kits and STRA loci, but differences in mutation rates on different STR loci. In the cases where mutations had occured, we found no interaction between kits, STRA loci or sexes. However, we found differences in the mutation rates between the sexes, meaning that the differences in male and female mutation rates can be assumed constant over STR loci and kits. Sex and STR locus specific mutation rates were estimated with 95% confidence limits by the method of Clopper and Pearson (1934).

AB - Danish paternity cases in the period 1999 to 2005 were investigated regarding mutation rates in STR loci. STR-typing was performed by the Applied Biosystems AmplfStr Profiler Plus kit in the period 1999 to early 2005, hereafter named the PP9, and by Applied Biosystems AmplfStr Identifier kit for the rest of 2005, hereafter named the IDFL. All cases with one to four genetic inconsistencies were manually inspected by two forensic geneticists and statistically analyzed by five statisticians. We found no significant effect of kits and no interaction of kits and STRA loci, but differences in mutation rates on different STR loci. In the cases where mutations had occured, we found no interaction between kits, STRA loci or sexes. However, we found differences in the mutation rates between the sexes, meaning that the differences in male and female mutation rates can be assumed constant over STR loci and kits. Sex and STR locus specific mutation rates were estimated with 95% confidence limits by the method of Clopper and Pearson (1934).

M3 - Poster

ER -

Andersen KE, Bøttcher SG, Christensen S, Eriksen PS, Højbjerre M, Hallenberg C et al. Mutation Rates of STR Systems in Danes. 2007. Poster session presented at International Society for Forensic Genetics (ISFG) Congress, Copenhagen, Denmark.