Mutational landscape of immune surveillance genes in diffuse large B-cell lymphoma

Marijana Nesic, Tarec Christoffer El-Galaly, Martin Bøgsted, Inge Søkilde Pedersen, Karen Dybkær*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Introduction: Immune surveillance is the dynamic process whereby the immune system identifies and kills tumor cells based on their aberrant expression of stress-related surface molecules or presentation of tumor neoantigens. It plays a crucial role in controlling the initiation and progression of hematologic cancers such as leukemia and lymphoma, and it has been reported that diffuse large B-cell lymphoma (DLBCL) fails to express specific cell-surface molecules that are necessary for the recognition and elimination of tumor cells.
Areas covered: This review is based on a systematic search strategy to identify relevant literature in the PubMed and Embase databases. Ten candidate genes are identified based on mutational frequency, and functions with detailed mapping performed for hotspot alterations that may have a functional impact on malignant transformation and decreased immune surveillance efficacy.
Expert opinion: Ongoing development of technology and bioinformatics tools combined with data from large clinical cohorts have the potential to define the mutational landscape associated with immune surveillance in DLBCL. Specific functional studies are required to make an unambiguous link between genetic aberrations and biological impact on impaired immune surveillance
Original languageEnglish
JournalExpert Review of Hematology
Volume13
Issue number6
Pages (from-to)655-668
Number of pages14
ISSN1747-4086
DOIs
Publication statusPublished - 2020

Keywords

  • DLBCL
  • Immune surveillance
  • candidate genes
  • immune escape
  • somatic mutation

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