MUTATIONS IN CALMODULIN GENES

Michael Toft Overgaard (Inventor), Mette Nyegaard (Inventor), Anders Børglum (Inventor)

Research output: Patent

Abstract

The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the polynucleotide and the polypeptide comprise at least one mutation associated with a cardiac disorder. The present invention also relates to a method for determining whether an individual has an increased risk of contracting a cardiac disorder, a method for diagnosing a cardiac disorder, method for treatment of an individual having a cardiac disorder, method for identifying a compound, capable of enhancing the binding of calmodulin to ryanodine receptor 2 and use of such compound in a treatment of an individual having a cardiac disorder. The invention further provides a kit that can be used to detect specific mutations in calmodulin encoding genes.
Original languageEnglish
IPCC07K 14/47
Patent numberPCT/EP2013/057726
CountryDenmark
Publication statusPublished - 17 Oct 2013

Bibliographical note

Applicants: AARHUS UNIVERSITET [DK]; AALBORG UNIVERSITET [DK]

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