Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

Alexander A. Artyukhov, Anna M. Nechaeva, Mikhail I. Shtilman, Evgeniy M. Chistyakov, Alina Yu Svistunova, Dmitry V. Bagrov, Andrey N. Kuskov, Anca O. Docea, Aristides M. Tsatsakis, Leonid Gurevich*, Yaroslav O. Mezhuev*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

10 Citations (Scopus)
49 Downloads (Pure)

Abstract

Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated.

Original languageEnglish
Article number7136
JournalMaterials
Volume15
Issue number20
ISSN1996-1944
DOIs
Publication statusPublished - Oct 2022

Bibliographical note

Funding Information:
This research was funded by the Ministry of Science and Higher Education of the Russian Federation. Agreement no. 075-15-2020-792, unique contract identifier RF----190220X0031.

Publisher Copyright:
© 2022 by the authors.

Keywords

  • doxorubicin delivery
  • poly(N-vinyl-2-pyrrolidone-co-acrylic acid) nanoparticles
  • release kinetics
  • targeting

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