Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system

Nanna Sutter; Mette Winther Klinge; Esben Bolvig Mark; Gursharan Nandhra; Anne-Mette Haase; Jakob Poulsen; Karoline Knudsen; Per Borghammer; Vincent Schlageter; Malcolm Birch; S Mark Scott; Asbjørn Mohr Drewes; Klaus Krogh

doi:10.1111/nmo.13829

Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system

Nanna Sutter, Mette Winther Klinge, Esben Bolvig Mark, Gursharan Nandhra, Anne-Mette Haase, Jakob Poulsen, Karoline Knudsen, Per Borghammer, Vincent Schlageter, Malcolm Birch, S Mark Scott, Asbjørn Mohr Drewes, Klaus Krogh

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

BACKGROUND: The Motilis 3D-Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method.

METHOD: A total of 132 healthy volunteers ingested the 3D-Transit capsule for assessment of gastrointestinal transit times. Recordings from 125 subjects were used for definition of normative values. Forty-six subjects were studied on two consecutive days. Recordings were reanalyzed using newly developed software providing information on gastric emptying (GE) as well as contraction frequency and movement during gastric contractions.

RESULTS: The median GE time was 2.7 hours (range 0.1-21.2). In 89% of subjects, the capsule passed the pylorus within a postingestion period of 6 hours. The median frequency of gastric contractions was 3.1 per minute (range 2.6-3.8). The frequency was higher in women (3.2, range 2.7-3.8) than in men (3.0, range 2.6-3.5) and increased with age (0.004 per year) (P < .05). The median amplitudes were 35° (range 4-85) when based on rotation of the capsule and 11 mm (range 6-31) when based on capsule change in position. The rotation amplitude was higher in women and decreased with increasing BMI (P < .05). The position amplitude was also higher in women and increased with the amount of calories in the test meal, but decreased with increasing BMI and age (P < .05). Day-to-day variation (P > .05) was considerable while inter-rater variability was small.

CONCLUSION AND INFERENCES: We have established normative values for gastric motility assessed with the 3D-Transit system.

Original language	English
Article number	e13829
Journal	Neurogastroenterology and Motility
Volume	32
Issue number	6
ISSN	1365-2982
DOIs	https://doi.org/10.1111/nmo.13829
Publication status	Published - Jun 2020

Keywords

gastric motility
gastroenterology
gastrointestinal motility
neurogastroenterology

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Scott_Normative values for gastric motility_Accepted-manuscript_2020Accepted author manuscript, 268 KB

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Sutter, N., Klinge, M. W., Mark, E. B., Nandhra, G., Haase, A-M., Poulsen, J., Knudsen, K., Borghammer, P., Schlageter, V., Birch, M., Scott, S. M., Drewes, A. M., & Krogh, K. (2020). Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system. Neurogastroenterology and Motility, 32(6), Article e13829. Advance online publication. https://doi.org/10.1111/nmo.13829

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title = "Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system",

abstract = "BACKGROUND: The Motilis 3D-Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method.METHOD: A total of 132 healthy volunteers ingested the 3D-Transit capsule for assessment of gastrointestinal transit times. Recordings from 125 subjects were used for definition of normative values. Forty-six subjects were studied on two consecutive days. Recordings were reanalyzed using newly developed software providing information on gastric emptying (GE) as well as contraction frequency and movement during gastric contractions.RESULTS: The median GE time was 2.7 hours (range 0.1-21.2). In 89% of subjects, the capsule passed the pylorus within a postingestion period of 6 hours. The median frequency of gastric contractions was 3.1 per minute (range 2.6-3.8). The frequency was higher in women (3.2, range 2.7-3.8) than in men (3.0, range 2.6-3.5) and increased with age (0.004 per year) (P < .05). The median amplitudes were 35° (range 4-85) when based on rotation of the capsule and 11 mm (range 6-31) when based on capsule change in position. The rotation amplitude was higher in women and decreased with increasing BMI (P < .05). The position amplitude was also higher in women and increased with the amount of calories in the test meal, but decreased with increasing BMI and age (P < .05). Day-to-day variation (P > .05) was considerable while inter-rater variability was small.CONCLUSION AND INFERENCES: We have established normative values for gastric motility assessed with the 3D-Transit system.",

keywords = "gastric motility, gastroenterology, gastrointestinal motility, neurogastroenterology",

author = "Nanna Sutter and Klinge, {Mette Winther} and Mark, {Esben Bolvig} and Gursharan Nandhra and Anne-Mette Haase and Jakob Poulsen and Karoline Knudsen and Per Borghammer and Vincent Schlageter and Malcolm Birch and Scott, {S Mark} and Drewes, {Asbj{\o}rn Mohr} and Klaus Krogh",

year = "2020",

month = jun,

doi = "10.1111/nmo.13829",

language = "English",

volume = "32",

journal = "Neurogastroenterology and Motility",

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T1 - Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system

AU - Sutter, Nanna

AU - Klinge, Mette Winther

AU - Mark, Esben Bolvig

AU - Nandhra, Gursharan

AU - Haase, Anne-Mette

AU - Poulsen, Jakob

AU - Knudsen, Karoline

AU - Borghammer, Per

AU - Schlageter, Vincent

AU - Birch, Malcolm

AU - Scott, S Mark

AU - Drewes, Asbjørn Mohr

AU - Krogh, Klaus

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: The Motilis 3D-Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method.METHOD: A total of 132 healthy volunteers ingested the 3D-Transit capsule for assessment of gastrointestinal transit times. Recordings from 125 subjects were used for definition of normative values. Forty-six subjects were studied on two consecutive days. Recordings were reanalyzed using newly developed software providing information on gastric emptying (GE) as well as contraction frequency and movement during gastric contractions.RESULTS: The median GE time was 2.7 hours (range 0.1-21.2). In 89% of subjects, the capsule passed the pylorus within a postingestion period of 6 hours. The median frequency of gastric contractions was 3.1 per minute (range 2.6-3.8). The frequency was higher in women (3.2, range 2.7-3.8) than in men (3.0, range 2.6-3.5) and increased with age (0.004 per year) (P < .05). The median amplitudes were 35° (range 4-85) when based on rotation of the capsule and 11 mm (range 6-31) when based on capsule change in position. The rotation amplitude was higher in women and decreased with increasing BMI (P < .05). The position amplitude was also higher in women and increased with the amount of calories in the test meal, but decreased with increasing BMI and age (P < .05). Day-to-day variation (P > .05) was considerable while inter-rater variability was small.CONCLUSION AND INFERENCES: We have established normative values for gastric motility assessed with the 3D-Transit system.

AB - BACKGROUND: The Motilis 3D-Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method.METHOD: A total of 132 healthy volunteers ingested the 3D-Transit capsule for assessment of gastrointestinal transit times. Recordings from 125 subjects were used for definition of normative values. Forty-six subjects were studied on two consecutive days. Recordings were reanalyzed using newly developed software providing information on gastric emptying (GE) as well as contraction frequency and movement during gastric contractions.RESULTS: The median GE time was 2.7 hours (range 0.1-21.2). In 89% of subjects, the capsule passed the pylorus within a postingestion period of 6 hours. The median frequency of gastric contractions was 3.1 per minute (range 2.6-3.8). The frequency was higher in women (3.2, range 2.7-3.8) than in men (3.0, range 2.6-3.5) and increased with age (0.004 per year) (P < .05). The median amplitudes were 35° (range 4-85) when based on rotation of the capsule and 11 mm (range 6-31) when based on capsule change in position. The rotation amplitude was higher in women and decreased with increasing BMI (P < .05). The position amplitude was also higher in women and increased with the amount of calories in the test meal, but decreased with increasing BMI and age (P < .05). Day-to-day variation (P > .05) was considerable while inter-rater variability was small.CONCLUSION AND INFERENCES: We have established normative values for gastric motility assessed with the 3D-Transit system.

KW - gastric motility

KW - gastroenterology

KW - gastrointestinal motility

KW - neurogastroenterology

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U2 - 10.1111/nmo.13829

DO - 10.1111/nmo.13829

M3 - Journal article

C2 - 32154975

SN - 1365-2982

VL - 32

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

IS - 6

M1 - e13829

ER -

Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system

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