Numerical investigation of the lower airway exposure to indoor particulate contaminants

Malthe H. Hvelplund, Li Liu, Kirstine Meyer Frandsen, Hua Qian, Peter V. Nielsen, Yuan Dai, Leitao Wen, Yingqi Zhang

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Inhalation exposure to indoor particulate contaminants contributes as one of the leading threats to public health. Most existing airway morphometry models are either theoretical or semi-empirical; these are developed for predicting deposition fractions for an averaged general population subgroup. It is difficult to customize a fast and accurate prediction on individual basis. This study aims to analyse the regional particle deposition along an anatomically correct airway model, which is developed from a healthy volunteer’s computer tomography images. Computational fluid dynamics simulation results show that the majority of particles are deposited in the bronchi. Accumulation particles (0.1–2.0 μm) have the smallest deposition fraction in the lower airways. An increase in the aerodynamic diameter >2.0 μm of the particles elevated the deposition fraction. These findings inspire future investigations into control methods that minimize the negative health impact of indoor emissions.
Original languageEnglish
JournalIndoor and Built Environment
ISSN1420-326X
DOIs
Publication statusPublished - 11 Sep 2019

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Inhalation Exposure
Hydrodynamics
Bronchi
Healthy Volunteers
Theoretical Models
Public Health
Tomography
Health
Population

Keywords

  • particle transport
  • particle deposition
  • respiratory system
  • realistic lung airway

Cite this

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title = "Numerical investigation of the lower airway exposure to indoor particulate contaminants",
abstract = "Inhalation exposure to indoor particulate contaminants contributes as one of the leading threats to public health. Most existing airway morphometry models are either theoretical or semi-empirical; these are developed for predicting deposition fractions for an averaged general population subgroup. It is difficult to customize a fast and accurate prediction on individual basis. This study aims to analyse the regional particle deposition along an anatomically correct airway model, which is developed from a healthy volunteer’s computer tomography images. Computational fluid dynamics simulation results show that the majority of particles are deposited in the bronchi. Accumulation particles (0.1–2.0 μm) have the smallest deposition fraction in the lower airways. An increase in the aerodynamic diameter >2.0 μm of the particles elevated the deposition fraction. These findings inspire future investigations into control methods that minimize the negative health impact of indoor emissions.",
keywords = "particle transport, particle deposition, respiratory system, realistic lung airway",
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Numerical investigation of the lower airway exposure to indoor particulate contaminants. / Hvelplund, Malthe H.; Liu, Li; Frandsen, Kirstine Meyer; Qian, Hua; Nielsen, Peter V.; Dai, Yuan; Wen, Leitao; Zhang, Yingqi.

In: Indoor and Built Environment, 11.09.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Numerical investigation of the lower airway exposure to indoor particulate contaminants

AU - Hvelplund, Malthe H.

AU - Liu, Li

AU - Frandsen, Kirstine Meyer

AU - Qian, Hua

AU - Nielsen, Peter V.

AU - Dai, Yuan

AU - Wen, Leitao

AU - Zhang, Yingqi

PY - 2019/9/11

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N2 - Inhalation exposure to indoor particulate contaminants contributes as one of the leading threats to public health. Most existing airway morphometry models are either theoretical or semi-empirical; these are developed for predicting deposition fractions for an averaged general population subgroup. It is difficult to customize a fast and accurate prediction on individual basis. This study aims to analyse the regional particle deposition along an anatomically correct airway model, which is developed from a healthy volunteer’s computer tomography images. Computational fluid dynamics simulation results show that the majority of particles are deposited in the bronchi. Accumulation particles (0.1–2.0 μm) have the smallest deposition fraction in the lower airways. An increase in the aerodynamic diameter >2.0 μm of the particles elevated the deposition fraction. These findings inspire future investigations into control methods that minimize the negative health impact of indoor emissions.

AB - Inhalation exposure to indoor particulate contaminants contributes as one of the leading threats to public health. Most existing airway morphometry models are either theoretical or semi-empirical; these are developed for predicting deposition fractions for an averaged general population subgroup. It is difficult to customize a fast and accurate prediction on individual basis. This study aims to analyse the regional particle deposition along an anatomically correct airway model, which is developed from a healthy volunteer’s computer tomography images. Computational fluid dynamics simulation results show that the majority of particles are deposited in the bronchi. Accumulation particles (0.1–2.0 μm) have the smallest deposition fraction in the lower airways. An increase in the aerodynamic diameter >2.0 μm of the particles elevated the deposition fraction. These findings inspire future investigations into control methods that minimize the negative health impact of indoor emissions.

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KW - particle deposition

KW - respiratory system

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