TY - JOUR
T1 - Obesity and risk of subsequent hospitalization with pneumonia
AU - Kornum, J B
AU - Nørgaard, M
AU - Dethlefsen, C
AU - Due, K M
AU - Thomsen, Reimar W.
AU - Tjønneland, A
AU - Sørensen, Henrik Toft
AU - Overvad, K
PY - 2010
Y1 - 2010
N2 - Obesity may be associated with increased risk of pneumonia, but available data are sparse and inconsistent.We followed a prospective cohort of 22,578 males and 25,973 females from the Danish Diet, Cancer and Health Study, aged 50-64 and free from major chronic diseases at baseline (1993-1997), for first-time hospitalization with pneumonia (median follow-up 12 years).Compared with males of normal weight, adjusted hazard ratios (HRs) of pneumonia were 1.4 (95% CI 1.2-1.7) for males with moderate obesity (BMI 30.0-34.9), and 2.0 (1.4-2.8) for males with severe obesity (BMI >/=35.0), controlling for lifestyle and educational variables. Among females the associations were weaker with adjusted HRs of 0.8 (0.6-1.0) for moderate obesity, and 1.2 (0.8-1.6) for severe obesity. Adjustment for major chronic diseases diagnosed during follow-up eliminated the associations between obesity and pneumonia risk.Obesity is associated with higher risk of hospitalization with pneumonia among males but not among females, apparently explained by occurrence of other chronic diseases.
AB - Obesity may be associated with increased risk of pneumonia, but available data are sparse and inconsistent.We followed a prospective cohort of 22,578 males and 25,973 females from the Danish Diet, Cancer and Health Study, aged 50-64 and free from major chronic diseases at baseline (1993-1997), for first-time hospitalization with pneumonia (median follow-up 12 years).Compared with males of normal weight, adjusted hazard ratios (HRs) of pneumonia were 1.4 (95% CI 1.2-1.7) for males with moderate obesity (BMI 30.0-34.9), and 2.0 (1.4-2.8) for males with severe obesity (BMI >/=35.0), controlling for lifestyle and educational variables. Among females the associations were weaker with adjusted HRs of 0.8 (0.6-1.0) for moderate obesity, and 1.2 (0.8-1.6) for severe obesity. Adjustment for major chronic diseases diagnosed during follow-up eliminated the associations between obesity and pneumonia risk.Obesity is associated with higher risk of hospitalization with pneumonia among males but not among females, apparently explained by occurrence of other chronic diseases.
U2 - 10.1183/09031936.00184209
DO - 10.1183/09031936.00184209
M3 - Journal article
SN - 0903-1936
VL - 36
SP - 1330
EP - 1336
JO - The European Respiratory Journal
JF - The European Respiratory Journal
ER -