OCCUPATIONAL EXPOSURE AND COPD

A DANISH POPULATION-BASED STUDY

Research output: Book/ReportPh.D. thesisResearch

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Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a common disease. The main risk factor is smoking although 15% of the COPD cases are expected to be preventable if the occupational exposures from vapour, gas, dust, and fume were eliminated; the population attributable fraction (PAF).

The thesis addresses the association between occupational exposure and COPD in a population-based cohort of Danes aged 45-84-years.

4717 participants were included at baseline and 2624 at the four year follow-up. COPD was defined by spirometry and the occupational exposure was based on specialist defined jobs and questionnaires. The main occupational exposure was organic dust and 49% reported no lifetime occupational exposure.

The results suggest occupational exposures to be associated to COPD also in never smokers and women. We found an exposure-response relation in the cross sectional analyses. The results are in accordance with other international studies. The estimated PAFs were high among never smokers, while no comparable PAF previously have been established among women. The analyses indicate an association between occupational exposure and incident COPD.

Recognising that exposures from work over time might have an impact on the development of COPD ought to be transformed to preventive efforts to eliminate occupational COPD and improve public health.
Original languageEnglish
PublisherAalborg Universitetsforlag
Number of pages161
ISBN (Electronic)978-87-7112-209-1
DOIs
Publication statusPublished - 2015
SeriesPh.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet
ISSN2246-1302

Cite this

Würtz, E. T. (2015). OCCUPATIONAL EXPOSURE AND COPD: A DANISH POPULATION-BASED STUDY. Aalborg Universitetsforlag. Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet https://doi.org/10.5278/vbn.phd.med.00030
Würtz, Else Toft. / OCCUPATIONAL EXPOSURE AND COPD : A DANISH POPULATION-BASED STUDY. Aalborg Universitetsforlag, 2015. 161 p. (Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet).
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title = "OCCUPATIONAL EXPOSURE AND COPD: A DANISH POPULATION-BASED STUDY",
abstract = "Chronic Obstructive Pulmonary Disease (COPD) is a common disease. The main risk factor is smoking although 15{\%} of the COPD cases are expected to be preventable if the occupational exposures from vapour, gas, dust, and fume were eliminated; the population attributable fraction (PAF).The thesis addresses the association between occupational exposure and COPD in a population-based cohort of Danes aged 45-84-years.4717 participants were included at baseline and 2624 at the four year follow-up. COPD was defined by spirometry and the occupational exposure was based on specialist defined jobs and questionnaires. The main occupational exposure was organic dust and 49{\%} reported no lifetime occupational exposure.The results suggest occupational exposures to be associated to COPD also in never smokers and women. We found an exposure-response relation in the cross sectional analyses. The results are in accordance with other international studies. The estimated PAFs were high among never smokers, while no comparable PAF previously have been established among women. The analyses indicate an association between occupational exposure and incident COPD.Recognising that exposures from work over time might have an impact on the development of COPD ought to be transformed to preventive efforts to eliminate occupational COPD and improve public health.",
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Würtz, ET 2015, OCCUPATIONAL EXPOSURE AND COPD: A DANISH POPULATION-BASED STUDY. Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet, Aalborg Universitetsforlag. https://doi.org/10.5278/vbn.phd.med.00030

OCCUPATIONAL EXPOSURE AND COPD : A DANISH POPULATION-BASED STUDY. / Würtz, Else Toft.

Aalborg Universitetsforlag, 2015. 161 p. (Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet).

Research output: Book/ReportPh.D. thesisResearch

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AB - Chronic Obstructive Pulmonary Disease (COPD) is a common disease. The main risk factor is smoking although 15% of the COPD cases are expected to be preventable if the occupational exposures from vapour, gas, dust, and fume were eliminated; the population attributable fraction (PAF).The thesis addresses the association between occupational exposure and COPD in a population-based cohort of Danes aged 45-84-years.4717 participants were included at baseline and 2624 at the four year follow-up. COPD was defined by spirometry and the occupational exposure was based on specialist defined jobs and questionnaires. The main occupational exposure was organic dust and 49% reported no lifetime occupational exposure.The results suggest occupational exposures to be associated to COPD also in never smokers and women. We found an exposure-response relation in the cross sectional analyses. The results are in accordance with other international studies. The estimated PAFs were high among never smokers, while no comparable PAF previously have been established among women. The analyses indicate an association between occupational exposure and incident COPD.Recognising that exposures from work over time might have an impact on the development of COPD ought to be transformed to preventive efforts to eliminate occupational COPD and improve public health.

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Würtz ET. OCCUPATIONAL EXPOSURE AND COPD: A DANISH POPULATION-BASED STUDY. Aalborg Universitetsforlag, 2015. 161 p. (Ph.d.-serien for Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet). https://doi.org/10.5278/vbn.phd.med.00030