Oral intake of bucillamine, carvedilol, metformin, or phenformin does not protect against UVR-induced squamous cell carcinomas in hairless mice

Celina Pihl*, Peter Bjerring, Flemming Andersen, Merete Haedersdal, Catharina M. Lerche

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Squamous cell carcinoma represents the second most common type of keratinocyte carcinoma with ultraviolet radiation (UVR) making up the primary risk factor. Oral photoprotection aims to reduce incidence rates through oral intake of photoprotective compounds. Recently, drug repurposing has gained traction as an interesting source of chemoprevention. Because of their reported photoprotective properties, we investigated the potential of bucillamine, carvedilol, metformin, and phenformin as photoprotective compounds following oral intake in UVR-exposed hairless mice. Tumour development was observed in all groups in response to UVR, with only the positive control (Nicotinamide) demonstrating a reduction in tumour incidence (23.8%). No change in tumour development was observed in the four repurposed drug groups compared to the UV control group, whereas nicotinamide significantly reduced carcinogenesis (P = 0.00012). Metformin treatment significantly reduced UVR-induced erythema (P = 0.012), bucillamine and phenformin increased dorsal pigmentation (P = 0.0013, and P = 0.0005), but no other photoprotective effect was observed across the repurposed groups. This study demonstrates that oral supplementation with bucillamine, carvedilol, metformin, or phenformin does not affect UVR-induced carcinogenesis in hairless mice.

Original languageEnglish
JournalPhotochemical & Photobiological Sciences
Volume23
Issue number3
Pages (from-to)517-526
Number of pages10
ISSN1474-9092
DOIs
Publication statusPublished - Mar 2024

Bibliographical note

© 2024. The Author(s).

Keywords

  • Drug repurposing
  • Hairless mice
  • Photoprotection
  • Skin cancer
  • Ultraviolet radiation

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