Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Morten Bentestuen; Camilla Sylvest; Anna Poulsgaard Frandsen; Helle D. Zacho

doi:10.1097/RLU.0000000000005586

Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Morten Bentestuen^*, Camilla Sylvest, Anna Poulsgaard Frandsen, Helle D. Zacho

^*Corresponding author for this work

Research output: Contribution to journal › Case Report › Research › peer-review

1 Citation (Scopus)

Abstract

A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

Original language	English
Journal	Clinical Nuclear Medicine
Volume	50
Issue number	3
Pages (from-to)	e178-e179
Number of pages	2
ISSN	0363-9762
DOIs	https://doi.org/10.1097/RLU.0000000000005586
Publication status	Published - 1 Mar 2025

Bibliographical note

Keywords

FAPI PET/CT
FDG PET/CT
ovarian clear cell carcinoma
ovarian neoplasms

Access to Document

10.1097/RLU.0000000000005586

AUB Link

Search for the material in Aalborg University Library's search engine

Cite this

@misc{0b12a2b9789e4525892bbdd2c45ebf81,

title = "Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report",

abstract = "A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.",

keywords = "FAPI PET/CT, FDG PET/CT, ovarian clear cell carcinoma, ovarian neoplasms",

author = "Morten Bentestuen and Camilla Sylvest and Frandsen, {Anna Poulsgaard} and Zacho, {Helle D.}",

year = "2025",

month = mar,

day = "1",

doi = "10.1097/RLU.0000000000005586",

language = "English",

volume = "50",

pages = "e178--e179",

journal = "Clinical Nuclear Medicine",

issn = "0363-9762",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "3",

}

TY - GEN

T1 - Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

AU - Bentestuen, Morten

AU - Sylvest, Camilla

AU - Frandsen, Anna Poulsgaard

AU - Zacho, Helle D.

PY - 2025/3/1

Y1 - 2025/3/1

N2 - A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

AB - A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

KW - FAPI PET/CT

KW - FDG PET/CT

KW - ovarian clear cell carcinoma

KW - ovarian neoplasms

UR - http://www.scopus.com/inward/record.url?scp=85210938805&partnerID=8YFLogxK

U2 - 10.1097/RLU.0000000000005586

DO - 10.1097/RLU.0000000000005586

M3 - Case Report

C2 - 39601076

SN - 0363-9762

VL - 50

SP - e178-e179

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

IS - 3

ER -

Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Abstract

Bibliographical note

Keywords

Access to Document

AUB Link

Other files and links

Fingerprint

Cite this