Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Morten Thorsen*, Niels Bilenberg, Lena Thorsen, Tanja Maria Michel

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

8 Citations (Scopus)

Abstract

Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume52
Issue number1
Pages (from-to)275-282
Number of pages8
ISSN0162-3257
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Autism Spectrum Disorder
  • Oxidative Stress
  • Sex
  • Superoxide Dismutase
  • Xanthine Oxidase

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