Abstract
The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/ catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF-I-like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.
| Original language | English |
|---|---|
| Journal | Aging Cell |
| Volume | 2 |
| Issue number | 6 |
| Pages (from-to) | 319-26 |
| Number of pages | 8 |
| ISSN | 1474-9718 |
| DOIs | |
| Publication status | Published - Dec 2003 |
| Externally published | Yes |
Keywords
- Aging
- Animals
- Antioxidants/pharmacology
- Caenorhabditis elegans/drug effects
- Catalase/antagonists & inhibitors
- Ethylenediamines/pharmacology
- Organometallic Compounds/pharmacology
- Oxidative Stress/drug effects
- Paraquat/toxicity
- Salicylates/pharmacology
- Superoxide Dismutase/antagonists & inhibitors