Pancreatic exocrine insufficiency in diabetes mellitus - prevalence and characteristics

Eirik Søfteland, Jakob Lykke Poulsen, Jakob Starup-Linde, Trine Tang Christensen, Søren Schou Olesen, Simran Singh, Peter Vestergaard, Asbjørn Mohr Drewes, Georg Dimcevski

Research output: Contribution to journalJournal articleResearchpeer-review

18 Citations (Scopus)

Abstract

Background: The prevalence of pancreatic exocrine insufficiency (PEI) in diabetes mellitus (DM) varies widely between studies, which may be explained by methodological problems. We aimed to establish the prevalence of PEI in DM using the faecal elastase-1 (FE-1) assay as a screening test, and to further investigate these patients by the mixed 13C-triglyceride ( 13C-MTG) breath test. Methods: One hundred and thirty-three consecutive type 1 or type 2 DM patients without known exocrine pancreatic disorders were recruited. Demographic parameters, stool consistency, stool frequency, routine laboratory tests, and the presence of DM complications were registered. An FE-1 value <200 μg/g was used as the screening cut-off for PEI, and patients with FE-1 values below this level were referred for a 13C-MTG breath test. Results: One hundred and two patients returned faecal samples. The prevalence of PEI as measured by low FE-1 was 13%. Insulin usage, type 1 DM, and DM duration were associated with low FE-1. Stool habits were unaffected by low FE-1. Twelve out of 13 patients with low FE-1 performed the breath test, which was normal in all cases. Conclusions: The prevalence of PEI defined by FE-1 was low in our mixed cohort of type 1 and 2 DM patients. Furthermore, there was a discrepancy between FE-1 and the breath test. Hence, the role of FE-1 in evaluating pancreatic exocrine function in DM should be evaluated in larger studies in order to clarify the association between low FE-1 and clinically relevant PEI.

Original languageEnglish
JournalEuropean Journal of Internal Medicine
Volume68
Pages (from-to)18-22
Number of pages5
ISSN0953-6205
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Diabetes mellitus
  • Faecal elastase-1
  • Mixed C-triglyceride breath test
  • Pancreatic exocrine insufficiency

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