Parental Age and Autism Spectrum Disorders

Erik Thorlund Parner; Simon Baron-Cohen; Marlene B Lauritsen; Meta Jørgensen; Laura A Schieve; Marshalyn Yeargin-Allsopp; Carsten Obel

doi:10.1016/j.annepidem.2011.12.006

Parental Age and Autism Spectrum Disorders

Erik Thorlund Parner, Simon Baron-Cohen, Marlene B Lauritsen, Meta Jørgensen, Laura A Schieve, Marshalyn Yeargin-Allsopp, Carsten Obel

Research output: Contribution to journal › Journal article › Research › peer-review

116 Citations (Scopus)

Abstract

PURPOSE: We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design. METHODS: Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10. RESULTS: A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10-1.34) to 1.65 (1.09-2.48) depending on combinations of parental age categories;

Original language	English
Journal	Annals of Epidemiology
Volume	22
Issue number	3
Pages (from-to)	143-150
ISSN	1047-2797
DOIs	https://doi.org/10.1016/j.annepidem.2011.12.006
Publication status	Published - Mar 2012
Externally published	Yes

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Cite this

@article{10676fbd98f2427ca962ee7cfd55d085,

title = "Parental Age and Autism Spectrum Disorders",

abstract = "PURPOSE: We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design. METHODS: Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10. RESULTS: A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10-1.34) to 1.65 (1.09-2.48) depending on combinations of parental age categories;",

author = "Parner, {Erik Thorlund} and Simon Baron-Cohen and Lauritsen, {Marlene B} and Meta J{\o}rgensen and Schieve, {Laura A} and Marshalyn Yeargin-Allsopp and Carsten Obel",

year = "2012",

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doi = "10.1016/j.annepidem.2011.12.006",

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volume = "22",

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journal = "Annals of Epidemiology",

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TY - JOUR

T1 - Parental Age and Autism Spectrum Disorders

AU - Parner, Erik Thorlund

AU - Baron-Cohen, Simon

AU - Lauritsen, Marlene B

AU - Jørgensen, Meta

AU - Schieve, Laura A

AU - Yeargin-Allsopp, Marshalyn

AU - Obel, Carsten

PY - 2012/3

Y1 - 2012/3

N2 - PURPOSE: We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design. METHODS: Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10. RESULTS: A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10-1.34) to 1.65 (1.09-2.48) depending on combinations of parental age categories;

AB - PURPOSE: We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design. METHODS: Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10. RESULTS: A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10-1.34) to 1.65 (1.09-2.48) depending on combinations of parental age categories;

U2 - 10.1016/j.annepidem.2011.12.006

DO - 10.1016/j.annepidem.2011.12.006

M3 - Journal article

C2 - 22277122

SN - 1047-2797

VL - 22

SP - 143

EP - 150

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 3

ER -