TY - JOUR
T1 - Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees
AU - Granata, Giuseppe
AU - Di Iorio, Riccardo
AU - Romanello, Roberto
AU - Iodice, Francesco
AU - Raspopovic, Stanisa
AU - Petrini, Francesco
AU - Strauss, Ivo
AU - Valle, Giacomo
AU - Stieglitz, Thomas
AU - Čvančara, Paul
AU - Andreu, David
AU - Divoux, Jean Louis
AU - Giraud, David
AU - Wauters, Loic
AU - Hiairrassary, Arthur
AU - Jensen, Winnie
AU - Micera, Silvestro
AU - Rossini, Paolo Maria
PY - 2018
Y1 - 2018
N2 - Objective: The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording “phantom” somatosensory evoked potentials from the corresponding brain areas. Methods: We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials. Results: We recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex. Conclusion: Our results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses. Significance: Somatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.
AB - Objective: The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording “phantom” somatosensory evoked potentials from the corresponding brain areas. Methods: We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials. Results: We recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex. Conclusion: Our results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses. Significance: Somatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.
KW - Neural interface
KW - Phantom hand
KW - Robotic hand prosthesis
KW - Somatosensory evoked potentials
KW - Somatosensory feedback
U2 - 10.1016/j.clinph.2018.02.138
DO - 10.1016/j.clinph.2018.02.138
M3 - Journal article
AN - SCOPUS:85044718168
SN - 1388-2457
VL - 129
SP - 1117
EP - 1120
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 6
ER -