Pig Ulnar Nerve Recording with Sinusoidal and Temporal Interference Stimulation

Leen Jabban, Mafalda Ribeiro, Felipe Rettore Andreis, Thomas Gomes Norgaard Dos Santos Nielsen, Benjamin W Metcalfe

Research output: Contribution to book/anthology/report/conference proceedingArticle in proceedingResearchpeer-review

Abstract

Temporal interference stimulation has been suggested as a method to reach deep targets during transcutaneous electrical stimulation. Despite its growing use in transcutaneous stimulation therapies, the mechanism of its operation is not fully understood. Recent efforts to fill that gap have focused on computational modelling, in vitro and in vivo experiments relying on physical observations - e.g., sensation or movement. This paper expands the current range of experimental methods by demonstrating in vivo extraneural recordings from the ulnar nerve of a pig while applying temporal interference stimulation at a location targeting a distal part of the nerve. The main aim of the experiment was to compare neural activation using sinusoidal stimulation (100 Hz, 2 kHz, 4 kHz) and temporal interference stimulation (2 kHz and 4 kHz). The recordings showed a significant increase in the magnitude of stimulation artefacts at higher frequencies. While those artefacts could be removed and provided an indication of the depth of modulation, they resulted in the saturation of the amplifiers, limiting the stimulation currents and amplifier gains used. The results of the 100 Hz sine wave stimulation showed clear neural activity correlated to the stimulation waveform. However, this was not observed with temporal interference stimulation. The results suggest that, despite its greater penetration, higher currents might be required to observe a neural response with temporal interference stimulation, and more complex artefact rejection techniques may be required to validate the method.

Original languageEnglish
Title of host publication2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Number of pages5
Volume2022
PublisherIEEE
Publication dateJul 2022
Pages5084-5088
ISBN (Print)978-1-7281-2783-5
ISBN (Electronic)978-1-7281-2782-8
DOIs
Publication statusPublished - Jul 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022
https://embc.embs.org/2022/

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/202215/07/2022
Internet address
SeriesI E E E Engineering in Medicine and Biology Society. Conference Proceedings
ISSN2375-7477

Bibliographical note

10.13039/501100001732-Danish National Research Foundation (Grant Number: DNRF121)

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