Plasma levels of marine n-3 polyunsaturated fatty acids and renal allograft survival

Ivar A Eide, Trond Jenssen, Anders Hartmann, Lien M Diep, Dag O Dahle, Anna V Reisæter, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, My Svensson

Research output: Contribution to journalJournal articleResearchpeer-review

17 Citations (Scopus)

Abstract

BACKGROUND: Marine n-3 polyunsaturated fatty acids (PUFAs) may exert beneficial effects on inflammation, fibrosis, endothelial function, lipid profile and blood pressure that may prevent graft loss.

METHODS: In this observational cohort study in Norwegian renal transplant recipients (n = 1990), transplanted between 1999 and 2011, associations between plasma marine n-3 PUFA levels and graft loss were assessed by multivariable Cox proportional hazard regression analysis. Plasma phospholipid fatty acid composition was determined by gas chromatography and individual fatty acids recorded as weight percentage (wt%) of total fatty acids in a stable phase 10 weeks after transplantation.

RESULTS: During a median follow-up time of 6.8 years, 569 (28.6%) renal allografts were lost, either due to patient death (n = 340, 59.8% of graft loss) or graft loss in surviving patients (n = 229, 40.2%). Plasma marine n-3 PUFA levels ranged from 1.35 to 23.87 wt%, with a median level of 7.95 wt% (interquartile range 6.20-10.03 wt%). When adjusting for established graft loss risk factors, there was a 11% reduced risk of graft loss for every 1.0 wt% increase in marine n-3 PUFA level [adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.84-0.93], and a 10% reduced risk of graft loss in surviving patients (adjusted HR 0.90; 95% CI 0.84-0.97).

CONCLUSION: High levels of plasma marine n-3 PUFAs were associated with better renal allograft survival.

Original languageEnglish
JournalNephrology, Dialysis, Transplantation
Volume31
Issue number1
Pages (from-to)160-167
Number of pages8
ISSN0931-0509
DOIs
Publication statusPublished - 2016

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