TY - JOUR
T1 - Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk
AU - Eussen, Simone Jpm
AU - Vollset, Stein Emil
AU - Hustad, Steinar
AU - Midttun, Oivind
AU - Meyer, Klaus
AU - Fredriksen, Ase
AU - Ueland, Per M
AU - Jenab, Mazda
AU - Slimani, Nadia
AU - Boffetta, Paolo
AU - Overvad, Kim
AU - Thorlacius-Ussing, Ole
AU - Tjonneland, Anne M
AU - Olsen, Anja
AU - Clavel-Chapelon, Francoise
AU - Boutron-Ruault, Marie-Christine
AU - Morois, Sophie
AU - Weikert, Cornelia
AU - Pishon, Tobias
AU - Linseisen, Jakob
AU - Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Zilis, Demosthenes
AU - Katsoulis, Michael
AU - Palli, Domenico
AU - Pala, Valeria
AU - Vineis, Paolo P
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H M
AU - Bueno-de-Mesquita, H Bas
AU - van Duijnhoven, Fränzel
AU - Skeie, Guri
AU - Muñoz, Xavier
AU - Martínez-García, Carmen
AU - Dorronsoro, Miren
AU - Ardanaz, Eva
AU - Navarro, Carmen
AU - Rodriguez, Laudina
AU - Van Guelpen, Bethany
AU - Palmqvist, Richard
AU - Manjer, Jonas
AU - Ericson, Ulrika C
AU - Bingham, Sheila A
AU - Khaw, Kay-Tee
AU - Norat, Teresa
AU - Riboli, Elio
AU - Thorlacius-Ussing, O.
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Among the B-vitamins, folate has been studied in greatest detail in relation to colorectal cancer (CRC) risk. Although B-vitamins other than folate are also essential for one-carbon metabolism, epidemiological studies on plasma vitamins B2, B6, and B12 and CRC risk are small and inconclusive. METHODS: In this nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1365 incident CRC cases were matched to 2319 controls for study center, age, and sex. We measured the sum of the B2 species riboflavin and flavin mononucleotide, and the sum of the B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks (RRs) for CRC were estimated with conditional logistic regression and adjusted for smoking status, education, physical activity, BMI, alcohol consumption, and intake of fiber and red and processed meat. RESULTS: Adjusted RRs comparing the highest to lowest quintile (95% confidence interval, Ptrend) were: 0.71 (0.56-0.91, 0.02) for vitamin B2, 0.68 (0.53-0.87, <0.001) for vitamin B6, and 1.02 (0.80-1.29, 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >/=30g alcohol/day. The polymorphisms were not associated with CRC. CONCLUSIONS: Results from this large European cohort study show that higher plasma concentrations of vitamins B2 and B6 are associated with a lower CRC risk.
AB - BACKGROUND: Among the B-vitamins, folate has been studied in greatest detail in relation to colorectal cancer (CRC) risk. Although B-vitamins other than folate are also essential for one-carbon metabolism, epidemiological studies on plasma vitamins B2, B6, and B12 and CRC risk are small and inconclusive. METHODS: In this nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1365 incident CRC cases were matched to 2319 controls for study center, age, and sex. We measured the sum of the B2 species riboflavin and flavin mononucleotide, and the sum of the B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks (RRs) for CRC were estimated with conditional logistic regression and adjusted for smoking status, education, physical activity, BMI, alcohol consumption, and intake of fiber and red and processed meat. RESULTS: Adjusted RRs comparing the highest to lowest quintile (95% confidence interval, Ptrend) were: 0.71 (0.56-0.91, 0.02) for vitamin B2, 0.68 (0.53-0.87, <0.001) for vitamin B6, and 1.02 (0.80-1.29, 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >/=30g alcohol/day. The polymorphisms were not associated with CRC. CONCLUSIONS: Results from this large European cohort study show that higher plasma concentrations of vitamins B2 and B6 are associated with a lower CRC risk.
U2 - 10.1158/1055-9965.EPI-10-0407
DO - 10.1158/1055-9965.EPI-10-0407
M3 - Journal article
SN - 1055-9965
VL - 19
SP - 2549
EP - 2561
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
ER -