Projects per year
Abstract
In pre-clinical studies, human adipose-derived stem cells (hASCs) have shown great promise as a treatment modality for healing of cutaneous wounds. The advantages of hASCs are that they are relatively easy to obtain in large numbers from basic liposuctions, they maintain their characteristics after long-term in vitro culture, and they possess low immunogenicity, which enables the use of hASCs from random donors. It has been hypothesized that hASCs exert their wound healing properties by reducing inflammation, inducing angiogenesis, and promoting fibroblast and keratinocyte growth. Due to the inherent variability associated with the donor-dependent nature of ASC-based products, it appears necessary that the quality of the different products is prospectively certified using a set of most relevant potency assays. In this review, we present an overview of the available methodologies to assess the Mode and the Mechanism of Action of hASCs, specifically in the wound healing scenario. In conclusion, we propose a panel of potential potency assays to include in the future production of ASC-based medicinal products.
Original language | English |
---|---|
Article number | 249 |
Journal | Stem Cell Research & Therapy |
Volume | 13 |
Issue number | 1 |
Pages (from-to) | 249 |
ISSN | 1757-6512 |
DOIs | |
Publication status | Published - 11 Jun 2022 |
Bibliographical note
© 2022. The Author(s).Keywords
- Adipose-derived stem cells
- Chronic wounds
- Mechanism of action
- Mode of action
- Potency assay
- Stem cell-based medicinal product
- Wound healing
Fingerprint
Dive into the research topics of 'Potency assays for human adipose-derived stem cells as a medicinal product toward wound healing'. Together they form a unique fingerprint.Projects
- 1 Active
-
Potency markers for Adipose-derived Stem Cells for treatment of Chronic Wounds
Ren, G., Porsborg, S. R., Fink, T., Peng, Q. & Zachar, V.
15/10/2018 → …
Project: Research