PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

C Fabbri; A Marsano; D Albani; A Chierchia; R Calati; A Drago; C Crisafulli; M Calabrò; S Kasper; R Lanzenberger; J Zohar; A Juven-Wetzler; D Souery; S Montgomery; J Mendlewicz; A Serretti

doi:10.1038/tpj.2014.15

PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

C Fabbri, A Marsano, D Albani, A Chierchia, R Calati, A Drago, C Crisafulli, M Calabrò, S Kasper, R Lanzenberger, J Zohar, A Juven-Wetzler, D Souery, S Montgomery, J Mendlewicz, A Serretti

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Abstract

Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.

Original language	English
Journal	The Pharmacogenomics Journal
Volume	14
Issue number	5
Pages (from-to)	463-72
Number of pages	10
ISSN	1470-269X
DOIs	https://doi.org/10.1038/tpj.2014.15
Publication status	Published - Oct 2014
Externally published	Yes

Keywords

Antidepressive Agents/pharmacology
Calcineurin/genetics
Depression/drug therapy
Humans
Receptors, Antigen, B-Cell/genetics
Signal Transduction/drug effects

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Fabbri, C., Marsano, A., Albani, D., Chierchia, A., Calati, R., Drago, A., Crisafulli, C., Calabrò, M., Kasper, S., Lanzenberger, R., Zohar, J., Juven-Wetzler, A., Souery, D., Montgomery, S., Mendlewicz, J., & Serretti, A. (2014). PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. The Pharmacogenomics Journal, 14(5), 463-72. https://doi.org/10.1038/tpj.2014.15

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title = "PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway",

abstract = "Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation. ",

keywords = "Antidepressive Agents/pharmacology, Calcineurin/genetics, Depression/drug therapy, Humans, Receptors, Antigen, B-Cell/genetics, Signal Transduction/drug effects",

author = "C Fabbri and A Marsano and D Albani and A Chierchia and R Calati and A Drago and C Crisafulli and M Calabr{\`o} and S Kasper and R Lanzenberger and J Zohar and A Juven-Wetzler and D Souery and S Montgomery and J Mendlewicz and A Serretti",

year = "2014",

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doi = "10.1038/tpj.2014.15",

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Fabbri, C, Marsano, A, Albani, D, Chierchia, A, Calati, R, Drago, A, Crisafulli, C, Calabrò, M, Kasper, S, Lanzenberger, R, Zohar, J, Juven-Wetzler, A, Souery, D, Montgomery, S, Mendlewicz, J & Serretti, A 2014, 'PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway', The Pharmacogenomics Journal, vol. 14, no. 5, pp. 463-72. https://doi.org/10.1038/tpj.2014.15

TY - JOUR

T1 - PPP3CC gene

T2 - a putative modulator of antidepressant response through the B-cell receptor signaling pathway

AU - Fabbri, C

AU - Marsano, A

AU - Albani, D

AU - Chierchia, A

AU - Calati, R

AU - Drago, A

AU - Crisafulli, C

AU - Calabrò, M

AU - Kasper, S

AU - Lanzenberger, R

AU - Zohar, J

AU - Juven-Wetzler, A

AU - Souery, D

AU - Montgomery, S

AU - Mendlewicz, J

AU - Serretti, A

PY - 2014/10

Y1 - 2014/10

N2 - Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.

AB - Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.

KW - Antidepressive Agents/pharmacology

KW - Calcineurin/genetics

KW - Depression/drug therapy

KW - Humans

KW - Receptors, Antigen, B-Cell/genetics

KW - Signal Transduction/drug effects

U2 - 10.1038/tpj.2014.15

DO - 10.1038/tpj.2014.15

M3 - Journal article

C2 - 24709691

SN - 1470-269X

VL - 14

SP - 463

EP - 472

JO - The Pharmacogenomics Journal

JF - The Pharmacogenomics Journal

IS - 5

ER -

PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

Abstract

Keywords

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