TY - JOUR
T1 - Præimplantationsgenetisk testning for aneuploidi
AU - Holmqvist, Viktoria
AU - Roos, Laura Kristine Soenderberg
AU - Kjartansdottir, Kristin Ros
AU - Dunø, Morten
AU - Hnida, Christina
AU - Pedersen, Inge Søkilde
AU - Ernst, Anja
AU - Toft, Christian Liebst Frisk
AU - Diemer, Tue
AU - Ingerslev, Hans Jakob
AU - Pinborg, Anja
AU - Løssl, Kristine
PY - 2019/5/13
Y1 - 2019/5/13
N2 - This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.
AB - This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.
UR - http://www.scopus.com/inward/record.url?scp=85066827056&partnerID=8YFLogxK
M3 - Tidsskriftartikel
C2 - 31124451
SN - 0041-5782
VL - 181
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
IS - 20
M1 - V12180849
ER -