Præimplantationsgenetisk testning for aneuploidi

Translated title of the contribution: Preimplantation genetic testing for aneuploidy

Viktoria Holmqvist, Laura Kristine Soenderberg Roos, Kristin Ros Kjartansdottir, Morten Dunø, Christina Hnida, Inge Søkilde Pedersen, Anja Ernst, Christian Liebst Frisk Toft, Tue Diemer, Hans Jakob Ingerslev, Anja Pinborg, Kristine Løssl

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.

Translated title of the contributionPreimplantation genetic testing for aneuploidy
Original languageDanish
Article numberV12180849
JournalUgeskrift for Laeger
Volume181
Issue number20
Number of pages4
ISSN0041-5782
Publication statusPublished - 13 May 2019

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