Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

Helene L Grønborg; Sanne Jespersen; Johanne H Egedal; Faustino G Correia; Candida Medina; Henrik Krarup; Bo L Hønge; Christian Wejse; Bissau HIV Cohort study group

doi:10.1111/tmi.13082

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

Helene L Grønborg, Sanne Jespersen, Johanne H Egedal, Faustino G Correia, Candida Medina, Henrik Krarup, Bo L Hønge, Christian Wejse, Bissau HIV Cohort study group

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

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Abstract

OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.

METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.

RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).

CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.

Original language	English
Journal	Tropical Medicine & International Health
Volume	23
Issue number	8
Pages (from-to)	896–904
Number of pages	9
ISSN	1360-2276
DOIs	https://doi.org/10.1111/tmi.13082
Publication status	Published - Aug 2018

Keywords

CMV prevalence
Clinical characteristics
Cytomegalovirus
Guinea-bissau
Hiv
Mortality

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10.1111/tmi.13082

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Grønborg, H. L., Jespersen, S., Egedal, J. H., Correia, F. G., Medina, C., Krarup, H., Hønge, B. L., Wejse, C., & Bissau HIV Cohort study group (2018). Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study. Tropical Medicine & International Health, 23(8), 896–904. https://doi.org/10.1111/tmi.13082

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title = "Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study",

abstract = "OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.",

keywords = "CMV prevalence, Clinical characteristics, Cytomegalovirus, Guinea-bissau, Hiv, Mortality",

author = "Gr{\o}nborg, {Helene L} and Sanne Jespersen and Egedal, {Johanne H} and Correia, {Faustino G} and Candida Medina and Henrik Krarup and H{\o}nge, {Bo L} and Christian Wejse and {Bissau HIV Cohort study group}",

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year = "2018",

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doi = "10.1111/tmi.13082",

language = "English",

volume = "23",

pages = "896–904",

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Grønborg, HL, Jespersen, S, Egedal, JH, Correia, FG, Medina, C, Krarup, H, Hønge, BL, Wejse, C & Bissau HIV Cohort study group 2018, 'Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study', Tropical Medicine & International Health, vol. 23, no. 8, pp. 896–904. https://doi.org/10.1111/tmi.13082

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study. / Grønborg, Helene L; Jespersen, Sanne; Egedal, Johanne H et al.
In: Tropical Medicine & International Health, Vol. 23, No. 8, 08.2018, p. 896–904.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau

T2 - a cross-sectional study

AU - Grønborg, Helene L

AU - Jespersen, Sanne

AU - Egedal, Johanne H

AU - Correia, Faustino G

AU - Medina, Candida

AU - Krarup, Henrik

AU - Hønge, Bo L

AU - Wejse, Christian

AU - Bissau HIV Cohort study group

PY - 2018/8

Y1 - 2018/8

N2 - OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.

AB - OBJECTIVES: To describe the prevalence of CMV in a cohort of HIV infected individuals in Guinea-Bissau, West Africa and to evaluate differences in patients' clinical characteristics associated with their CMV status.METHODS: Newly diagnosed HIV infected adults were invited to participate in this cross-sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV disease manifestations. Blood samples were analysed for CMV serology, QuantiFERON-CMV response and CMV DNA. Mortality follow-up were registered for one year after inclusion.RESULTS: In total, 180 patients were enrolled. Anti-CMV IgG positivity was found in 100% (138/138) and 2.8% (4/138) were anti-CMV IgM positive. A positive QuantiFERON-CMV response was found in 85.7% (60/70) of the patients and 60.6% (83/137) had CMV viraemia. QuantiFERON-CMV response and detectable CMV DNA were associated with lower CD4 cell count, older age and upper gastrointestinal complaints. During one year of follow-up, the IRR for death among CMV DNA positive patients was 1.5 (P = 0.5).CONCLUSIONS: CMV coinfection was detected among all enrolled patients and CMV viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients' CMV status.

KW - CMV prevalence

KW - Clinical characteristics

KW - Cytomegalovirus

KW - Guinea-bissau

KW - Hiv

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=85054567070&partnerID=8YFLogxK

U2 - 10.1111/tmi.13082

DO - 10.1111/tmi.13082

M3 - Journal article

C2 - 29851192

SN - 1360-2276

VL - 23

SP - 896

EP - 904

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

IS - 8

ER -

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

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