Quantitative flow ratio versus fractional flow reserve for guiding percutaneous coronary intervention: design and rationale of the randomised FAVOR III Europe Japan trial

Birgitte Krogsgaard Andersen, Martin Sejr-Hansen, Jelmer Westra, Gianluca Campo, Ashkan Efterkhari, Shengxian Tu, Javier Escaned, Lukasz Koltowski, Barbara E. Stähli, Andrejs Erglis, Gediminas Jaruševičius, Greta Žiubrytė, Truls Råmunddal, Tommy Liu, William Wijns, Ulf Landmesser, Luc Maillard, Hitoshi Matsuo, Evald Høj Christiansen, Niels Ramsing Holm

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)

Abstract

Quantitative flow ratio (QFR) is a computation of fractional flow reserve (FFR) based on invasive coronary angiographic images. Calculating QFR is less invasive than measuring FFR and may be associated with lower costs. Current evidence supports the call for an adequately powered randomised comparison of QFR and FFR for the evaluation of intermediate coronary stenosis. The aim of the FAVOR III Europe Japan trial is to investigate if a QFR-based diagnostic strategy yields a non-inferior 12-month clinical outcome compared with a standard FFR-guided strategy in the evaluation of patients with intermediary coronary stenosis. FAVOR III Europe Japan is an investigator-initiated, randomised, clinical outcome, non-inferiority trial scheduled to randomise 2,000 patients with either 1) stable angina pectoris and intermediate coronary stenosis, or 2) indications for functional assessment of at least 1 non-culprit lesion after acute myocardial infarction. Up to 40 international centres will randomise patients to either a QFR-based or a standard FFR-based diagnostic strategy. The primary endpoint of major adverse cardiovascular events is a composite of all-cause mortality, any myocardial infarction, and any unplanned coronary revascularisation at 12 months. QFR could emerge as an adenosine- and wire-free alternative to FFR, making the functional evaluation of intermediary coronary stenosis less invasive and more cost-effective.

Original languageEnglish
JournalEuroIntervention
Volume18
Issue number16
Pages (from-to)E1357-E1364
ISSN1774-024X
DOIs
Publication statusPublished - 3 Apr 2023

Keywords

  • clinical research
  • clinical trials
  • fractional flow reserve
  • other imaging modalities

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