TY - JOUR
T1 - Questionnaire-based assessment of sleep disorders in an adult population of Tuberous Sclerosis Complex
AU - Moavero, Romina
AU - Voci, Alessandra
AU - Romigi, Andrea
AU - Bisulli, Francesca
AU - Luisi, Concetta
AU - Matricardi, Sara
AU - La Briola, Francesca
AU - Mazzone, Luigi
AU - Valeriani, Massimiliano
AU - Curatolo, Paolo
AU - Bruni, Oliviero
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - BACKGROUND AND OBJECTIVE: Tuberous Sclerosis Complex (TSC) is a rare systemic disease with a high prevalence of sleep disorders (SD), although they are still largely under-recognized. The objective of this study was to assess the prevalence of SD in adult patients with TSC, and to evaluate the relationship between sleep, epilepsy, and TSC associated neuropsychiatric disorders (TAND).MATERIALS AND METHODS: We administered Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS) to 114 adult patients referring to different Italian centers. We also collected information on epilepsy and TAND.RESULTS: PSQI, ISI, and ESS revealed a positive score, respectively, in 52 (46.0%), 30 (26.5%), and 16 (14.1%) patients. PSQI was positive in 26.7% of seizure free patients versus 61.9% with active epilepsy (p = 0.003), and the association remained significative applying a multivariate logistic model considering age, antiseizure medications, TAND and nocturnal epileptic seizures (p = 0.02). ISI was positive in 3.3% of seizure free patients versus 41.3% with active epilepsy (p = 0.0004). Applying a multivariate logistic model with the independent variables listed above, the association remained significant (p = 0.007). On the other hand, multivariate logistic model considering active epilepsy as an independent variable, revealed that TAND didn't appear a significant risk factor for positive PSQI (p = 0.43) nor ISI (p = 0.09).CONCLUSIONS: Our results confirmed that SD are highly prevalent in adults with TSC, with active epilepsy acting as a significant risk factor. A careful assessment of sleep, above all in epileptic patients, is of crucial importance.
AB - BACKGROUND AND OBJECTIVE: Tuberous Sclerosis Complex (TSC) is a rare systemic disease with a high prevalence of sleep disorders (SD), although they are still largely under-recognized. The objective of this study was to assess the prevalence of SD in adult patients with TSC, and to evaluate the relationship between sleep, epilepsy, and TSC associated neuropsychiatric disorders (TAND).MATERIALS AND METHODS: We administered Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS) to 114 adult patients referring to different Italian centers. We also collected information on epilepsy and TAND.RESULTS: PSQI, ISI, and ESS revealed a positive score, respectively, in 52 (46.0%), 30 (26.5%), and 16 (14.1%) patients. PSQI was positive in 26.7% of seizure free patients versus 61.9% with active epilepsy (p = 0.003), and the association remained significative applying a multivariate logistic model considering age, antiseizure medications, TAND and nocturnal epileptic seizures (p = 0.02). ISI was positive in 3.3% of seizure free patients versus 41.3% with active epilepsy (p = 0.0004). Applying a multivariate logistic model with the independent variables listed above, the association remained significant (p = 0.007). On the other hand, multivariate logistic model considering active epilepsy as an independent variable, revealed that TAND didn't appear a significant risk factor for positive PSQI (p = 0.43) nor ISI (p = 0.09).CONCLUSIONS: Our results confirmed that SD are highly prevalent in adults with TSC, with active epilepsy acting as a significant risk factor. A careful assessment of sleep, above all in epileptic patients, is of crucial importance.
KW - Adult
KW - Epilepsy/epidemiology
KW - Humans
KW - Sleep
KW - Sleep Wake Disorders/epidemiology
KW - Surveys and Questionnaires
KW - Tuberous Sclerosis/complications
KW - Sleep disorders
KW - Neuropsychiatric disorders
KW - Epilepsy
KW - Tuberous sclerosis
KW - Adults
UR - http://www.scopus.com/inward/record.url?scp=85127210767&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2022.03.006
DO - 10.1016/j.sleep.2022.03.006
M3 - Journal article
C2 - 35364407
SN - 1389-9457
VL - 92
SP - 81
EP - 87
JO - Sleep Medicine
JF - Sleep Medicine
ER -