TY - JOUR
T1 - Recovery of renal function succeeding stem cell transplant
T2 - a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
AU - Andersen, Camilla Aakjær
AU - Marcussen, Niels
AU - Gregersen, Jon Waarst
PY - 2013/12
Y1 - 2013/12
N2 - Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway of complement. In previously reported cases of MPGN and C3 GN secondary to monoclonal gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the first patient, to our knowledge, who showed full renal recovery and normalization of the complement system after chemotherapy and stem cell transplantation.
AB - Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway of complement. In previously reported cases of MPGN and C3 GN secondary to monoclonal gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the first patient, to our knowledge, who showed full renal recovery and normalization of the complement system after chemotherapy and stem cell transplantation.
U2 - 10.1093/ckj/sft124
DO - 10.1093/ckj/sft124
M3 - Journal article
C2 - 26069834
SN - 2048-8505
VL - 6
SP - 639
EP - 642
JO - Clinical Kidney Journal
JF - Clinical Kidney Journal
IS - 6
ER -