Rectal Mechano-sensory Function in Patients with Carcinoid Diarrhea

Tine Gregersen, Christina Brock, Anne-Mette Haase, Soren Laurberg, Asbjørn Drewes, Henning Gronbaek, Klaus Krogh

Research output: Contribution to journalJournal articleResearchpeer-review

4 Citations (Scopus)

Abstract

Background/Aims: In patients with neuroendocrine tumors (NETs), excessive production of serotonin and other amines may cause the carcinoid syndrome, which is mainly characterized by diarrhea and flushing. Little is known about the pathophysiology of carcinoid diarrhea. In several other groups of patients, diarrhea may be associated with rectal hypersensitivity and increased rectal tone. Therefore, the aim of the present study was to compare rectal sensitivity and compliance in patients with carcinoid diarrhea and in healthy subjects.

Methods: Twelve patients (6 males, aged 54-78 years, median 65 years), with carcinoid diarrhea and 19 healthy subjects (7 males, aged 50-78 years, median 61 years) were included. Rectal mechanical and heat stimulation was used for assessment of rectal mechano-sensory properties.

Results: Overall, 5.3% higher temperatures were needed to elicit sensory responses in patients with carcinoid diarrhea than in healthy subjects (P = 0.02). Posthoc analyses revealed that the sensory threshold to heat was 48.1°C ± 3.1°C in patients vs 44.7°C ± 4.7°C in healthy subjects (P = 0.04). In contrast, patients and healthy subjects showed no overall differences in rectal sensory response to mechanical distension (P = 0.73) or rectal compliance (P = 0.99).

Conclusions: Patients with carcinoid diarrhea have higher sensory thresholds to heat stimulation in comparison to healthy subjects, but normal rectal sensation to mechanical distension and normal compliance. Therefore, treatment of carcinoid diarrhea should aim at prolonging gastrointestinal transit and decreasing secretion rather that modifying rectal mechano-sensory function.

Original languageEnglish
JournalNeurogastroenterology and Motility
Volume22
Issue number2
Pages (from-to)264-271
Number of pages8
ISSN1365-2982
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'Rectal Mechano-sensory Function in Patients with Carcinoid Diarrhea'. Together they form a unique fingerprint.

Cite this