Renal function and the associated risk of bacteraemia

INTRODUCTION: Chronic kidney disease is associated with increased risk of infection; however, this has predominantly been demonstrated in patients on renal replacement therapy. Few studies in selected populations have previously shown a correlation of risk of all-cause infection with decline in renal function. The aim of the present study was to examine the relationship between estimated GFR (eGFR) and risk of bacteraemia in a nationwide population cohort with exclusion of patients on renal replacement therapy.METHODS: Based on data from multiple nationwide health care registers, all patients with ≥1 recorded plasma creatinine measurement were identified in Denmark between 2008 and 2017. Patients entered the model following a 30-day quarantine period. All patients \lt;18 years, patients with preceding renal replacement therapy, and patients with events within the 30 days quarantine period were excluded. eGFR was estimated using the CKD-EPI equation, and standardized one-years risk of bacteraemia were estimated based on G-computation of multiple cause-specific Cox regression models permitting comparison of risk across strata of renal dysfunction (eGFR [ml/min/1.73m2] \gt;90, 90-61, 60-46, 45-31, 30-16, and ≤15, respectively).