Risk factors for incident asthma and COPD in a cohort of young adults

Lisbet Krogh Traulsen; Jesper Bælum; Anders Halling; Gert Thomsen; Trine Thilsing; David Sherson; Torben Sigsgaard; Øyvind Omland; Tine Malling; Lars Rauff Skadhauge

doi:10.1111/crj.12622

Risk factors for incident asthma and COPD in a cohort of young adults

Lisbet Krogh Traulsen, Jesper Bælum, Anders Halling, Gert Thomsen, Trine Thilsing, David Sherson, Torben Sigsgaard, Øyvind Omland, Tine Malling, Lars Rauff Skadhauge

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study.

METHODS: From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.

RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1,000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1 <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1 <100% predicted (all male cases had FEV1 <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34).

CONCLUSIONS: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasise considerable gender differences. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Clinical Respiratory Journal
Volume	12
Issue number	3
Pages (from-to)	1021-1029
Number of pages	9
ISSN	1752-6981
DOIs	https://doi.org/10.1111/crj.12622
Publication status	Published - Mar 2018

Keywords

Journal Article
epidemiology
cohort study
asthma
adult
risk factor
COPD
Spirometry
Follow-Up Studies
Humans
Male
Asthma/diagnosis
Incidence
Forced Expiratory Volume
Young Adult
Time Factors
Adult
Female
Comorbidity/trends
Skin Tests
Risk Assessment
Risk Factors
Population Surveillance/methods
Pulmonary Disease, Chronic Obstructive/diagnosis
Vital Capacity
Denmark/epidemiology
Sex Factors

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@article{2f75a9963378495b82f2a99338d93207,

title = "Risk factors for incident asthma and COPD in a cohort of young adults",

abstract = "INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study.METHODS: From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1,000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1 <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1 <100% predicted (all male cases had FEV1 <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34).CONCLUSIONS: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasise considerable gender differences. This article is protected by copyright. All rights reserved.",

keywords = "Journal Article, epidemiology, cohort study, asthma, adult, risk factor, COPD, Spirometry, Follow-Up Studies, Humans, Male, Asthma/diagnosis, Incidence, Forced Expiratory Volume, Young Adult, Time Factors, Adult, Female, Comorbidity/trends, Skin Tests, Risk Assessment, Risk Factors, Population Surveillance/methods, Pulmonary Disease, Chronic Obstructive/diagnosis, Vital Capacity, Denmark/epidemiology, Sex Factors",

author = "Traulsen, {Lisbet Krogh} and Jesper B{\ae}lum and Anders Halling and Gert Thomsen and Trine Thilsing and David Sherson and Torben Sigsgaard and {\O}yvind Omland and Tine Malling and Skadhauge, {Lars Rauff}",

note = "{\textcopyright} 2017 John Wiley & Sons Ltd.",

year = "2018",

month = mar,

doi = "10.1111/crj.12622",

language = "English",

volume = "12",

pages = "1021--1029",

journal = "Clinical Respiratory Journal",

issn = "1752-6981",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Risk factors for incident asthma and COPD in a cohort of young adults

AU - Traulsen, Lisbet Krogh

AU - Bælum, Jesper

AU - Halling, Anders

AU - Thomsen, Gert

AU - Thilsing, Trine

AU - Sherson, David

AU - Sigsgaard, Torben

AU - Omland, Øyvind

AU - Malling, Tine

AU - Skadhauge, Lars Rauff

PY - 2018/3

Y1 - 2018/3

N2 - INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study.METHODS: From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1,000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1 <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1 <100% predicted (all male cases had FEV1 <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34).CONCLUSIONS: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasise considerable gender differences. This article is protected by copyright. All rights reserved.

AB - INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study.METHODS: From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1,000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1 <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1 <100% predicted (all male cases had FEV1 <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34).CONCLUSIONS: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasise considerable gender differences. This article is protected by copyright. All rights reserved.

KW - Journal Article

KW - epidemiology

KW - cohort study

KW - asthma

KW - adult

KW - risk factor

KW - COPD

KW - Spirometry

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Asthma/diagnosis

KW - Incidence

KW - Forced Expiratory Volume

KW - Young Adult

KW - Time Factors

KW - Adult

KW - Female

KW - Comorbidity/trends

KW - Skin Tests

KW - Risk Assessment

KW - Risk Factors

KW - Population Surveillance/methods

KW - Pulmonary Disease, Chronic Obstructive/diagnosis

KW - Vital Capacity

KW - Denmark/epidemiology

KW - Sex Factors

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U2 - 10.1111/crj.12622

DO - 10.1111/crj.12622

M3 - Journal article

C2 - 28268257

SN - 1752-6981

VL - 12

SP - 1021

EP - 1029

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

IS - 3

ER -

Risk factors for incident asthma and COPD in a cohort of young adults

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