Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Kristina Öbrink-Hansen; Ole S Søgaard; Zitta B Harboe; Henrik C Schønheyder

Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Kristina Öbrink-Hansen, Ole S Søgaard, Zitta B Harboe, Henrik C Schønheyder

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

Original language	English
Journal	Current H I V Research
Volume	10
Pages (from-to)	252-5
Number of pages	4
ISSN	1570-162X
Publication status	Published - 2012
Externally published	Yes

Keywords

AIDS-Related Opportunistic Infections
CD4-Positive T-Lymphocytes
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Cohort Studies
Colony Count, Microbial
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nasopharynx
Pneumococcal Infections
Pneumococcal Vaccines
Randomized Controlled Trials as Topic
Risk Factors
Smoking
Streptococcus pneumoniae
Vaccines, Conjugate

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title = "Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report",

abstract = "HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.",

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author = "Kristina {\"O}brink-Hansen and S{\o}gaard, {Ole S} and Harboe, {Zitta B} and Sch{\o}nheyder, {Henrik C}",

year = "2012",

language = "English",

volume = "10",

pages = "252--5",

journal = "Current H I V Research",

issn = "1570-162X",

publisher = "Bentham Science Publishers Ltd.",

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TY - JOUR

T1 - Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV

T2 - brief report

AU - Öbrink-Hansen, Kristina

AU - Søgaard, Ole S

AU - Harboe, Zitta B

AU - Schønheyder, Henrik C

PY - 2012

Y1 - 2012

N2 - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

AB - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

KW - AIDS-Related Opportunistic Infections

KW - CD4-Positive T-Lymphocytes

KW - Clinical Trials, Phase I as Topic

KW - Clinical Trials, Phase II as Topic

KW - Cohort Studies

KW - Colony Count, Microbial

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Nasopharynx

KW - Pneumococcal Infections

KW - Pneumococcal Vaccines

KW - Randomized Controlled Trials as Topic

KW - Risk Factors

KW - Smoking

KW - Streptococcus pneumoniae

KW - Vaccines, Conjugate

M3 - Journal article

SN - 1570-162X

VL - 10

SP - 252

EP - 255

JO - Current H I V Research

JF - Current H I V Research

ER -

Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Abstract

Keywords

AUB Link

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