RNA Modification in Inflammatory Bowel Diseases

Mika Nakayama; Yuki Ozato; Yoshiko Tsuji; Yasuko Arao; Chihiro Otsuka; Yumiko Hamano; Genzo Sumi; Ken Ofusa; Shizuka Uchida; Andrea Vecchione; Hideshi Ishii

doi:10.3390/biomedicines10071695

RNA Modification in Inflammatory Bowel Diseases

Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

25 Downloads (Pure)

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.

Original language	English
Article number	1695
Journal	Biomedicines
Volume	10
Issue number	7
ISSN	2227-9059
DOIs	https://doi.org/10.3390/biomedicines10071695
Publication status	Published - 13 Jul 2022

Keywords

RNA modification
inflammatory bowel disease

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10.3390/biomedicines10071695Licence: CC BY 4.0

Nakayama et al. (2022). RNA Modification in Inflammatory Bowel DiseasesFinal published version, 2.31 MBLicence: CC BY 4.0

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title = "RNA Modification in Inflammatory Bowel Diseases",

abstract = "Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.",

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AU - Nakayama, Mika

AU - Ozato, Yuki

AU - Tsuji, Yoshiko

AU - Arao, Yasuko

AU - Otsuka, Chihiro

AU - Hamano, Yumiko

AU - Sumi, Genzo

AU - Ofusa, Ken

AU - Uchida, Shizuka

AU - Vecchione, Andrea

AU - Ishii, Hideshi

PY - 2022/7/13

Y1 - 2022/7/13

N2 - Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.

AB - Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.

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KW - inflammatory bowel disease

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U2 - 10.3390/biomedicines10071695

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RNA Modification in Inflammatory Bowel Diseases

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