TY - JOUR
T1 - Seismocardiography as a tool for assessment of bi-ventricular pacing
AU - Sørensen, Kasper
AU - Søgaard, Peter
AU - Emerek, Kasper
AU - Schou Jensen, Ask
AU - Struijk, Johannes Jan
AU - Schmidt, Samuel E
N1 - © 2022 Institute of Physics and Engineering in Medicine.
PY - 2022/10/26
Y1 - 2022/10/26
N2 -
Objective.Conduction-induced heart failure in patients with left bundle branch block (LBBB) can benefit from cardiac resynchronization therapy (CRT). However, some patients are non-responders to the therapy with one contributing factor being poor optimization of the atrioventricular (AV) pacing delay. In this study, we have investigated the pacing-induced changes in the seismocardiogram (SCG).
Approach.14 patients with heart failure, LBBB, and CRT were included. SCG was recorded with pacing turned on and off. Based on a mean SCG heartbeat from each patient, fiducial points were annotated, and cardiac timing intervals (CTI) and amplitudes were derived. These were compared between the CRT group and a group of healthy normal subjects (
n= 14). Echocardiography was also used to derive CTI. Intervals derived from the SCG and echocardiogram were correlated.
Main results.The isovolumetric contraction time (IVCT) derived from SCG was significantly shorter in the CRT group when the pacemaker was turned on (63.2-52.6 ms,
p= 0.027). The first peak-to-peak amplitude in the systolic complex was significantly larger with the pacemaker turned on (
p= 0.002), as well as the ∣max-min∣ amplitude in the systolic complex (
p= 0.003). Isovolumetric relaxation time and left ventricular ejection time (LVET) were not significantly different between pacemaker settings. Compared to normal subjects, IVCT was significantly prolonged with the pacemaker turned off. All amplitudes were significantly larger in the healthy subject group. IVCT and LVET derived from SCG were significantly correlated to the echocardiogram.
Significance.IVCT shortened and SCG amplitudes increased in response to CRT, indicating a more efficient ventricular contraction. This demonstrates the possibility to detect cardio-mechanic changes in response to treatment with the SCG. However, for the patients the systolic part of the SCG was abnormal and difficult to characterize, raising concerns about the correct interpretation of the SCG.
AB -
Objective.Conduction-induced heart failure in patients with left bundle branch block (LBBB) can benefit from cardiac resynchronization therapy (CRT). However, some patients are non-responders to the therapy with one contributing factor being poor optimization of the atrioventricular (AV) pacing delay. In this study, we have investigated the pacing-induced changes in the seismocardiogram (SCG).
Approach.14 patients with heart failure, LBBB, and CRT were included. SCG was recorded with pacing turned on and off. Based on a mean SCG heartbeat from each patient, fiducial points were annotated, and cardiac timing intervals (CTI) and amplitudes were derived. These were compared between the CRT group and a group of healthy normal subjects (
n= 14). Echocardiography was also used to derive CTI. Intervals derived from the SCG and echocardiogram were correlated.
Main results.The isovolumetric contraction time (IVCT) derived from SCG was significantly shorter in the CRT group when the pacemaker was turned on (63.2-52.6 ms,
p= 0.027). The first peak-to-peak amplitude in the systolic complex was significantly larger with the pacemaker turned on (
p= 0.002), as well as the ∣max-min∣ amplitude in the systolic complex (
p= 0.003). Isovolumetric relaxation time and left ventricular ejection time (LVET) were not significantly different between pacemaker settings. Compared to normal subjects, IVCT was significantly prolonged with the pacemaker turned off. All amplitudes were significantly larger in the healthy subject group. IVCT and LVET derived from SCG were significantly correlated to the echocardiogram.
Significance.IVCT shortened and SCG amplitudes increased in response to CRT, indicating a more efficient ventricular contraction. This demonstrates the possibility to detect cardio-mechanic changes in response to treatment with the SCG. However, for the patients the systolic part of the SCG was abnormal and difficult to characterize, raising concerns about the correct interpretation of the SCG.
KW - Bundle-Branch Block/diagnostic imaging
KW - Cardiac Resynchronization Therapy/methods
KW - Electrocardiography
KW - Heart Failure/diagnostic imaging
KW - Heart Ventricles/diagnostic imaging
KW - Humans
KW - Pacemaker, Artificial
KW - Treatment Outcome
KW - isovolumic contraction time (IVCT)
KW - left ventricular ejection time (LVET)
KW - biventricular pacing
KW - cardiac vibrations
KW - cardiac timing intervals
KW - seismocardiography (SCG)
KW - left bundle branch block (LBBB)
UR - http://www.scopus.com/inward/record.url?scp=85140857089&partnerID=8YFLogxK
U2 - 10.1088/1361-6579/ac94b2
DO - 10.1088/1361-6579/ac94b2
M3 - Journal article
C2 - 36150374
SN - 0967-3334
VL - 43
JO - Physiological Measurement
JF - Physiological Measurement
IS - 10
M1 - 105007
ER -