TY - JOUR
T1 - Selenium serum and urine is associated to mild asthma and atopy. The SUS study
AU - Omland, Øyvind
AU - Deguchi, Yoji
AU - Sigsgaard, Torben
AU - Hansen, Jens Carl
PY - 2002/1/1
Y1 - 2002/1/1
N2 - To examine the associations between selenium (Se) status, asthma, bronchial hyperresponsiveness (BHR), and atopy in 154 male subjects (72 with mild asthma, 41 with BHR and 41 with no respiratory symptoms) aged 18 (range 17-22) years. Each subject underwent a medical interview and FEV1 and FVC were recorded. Histamine bronchial reactivity (Yan method) was measured, skin prick test (inhalant allergens) was performed and Se in urine and serum was analysed (AOAC modified fluometric method). Se in serum 74.04 (10.58) μg/L (mean (SD)) was lower in subjects with asthma and the logarithm of the ratio of Se in serum (μg/L) and urine standardised to creatinine excretion (ng/mg creatinine) 0.748 (0.096) (mean (SD)) was lower in subjects with asthma and atopy compared to subjects with no allergic symptoms 77.79 (10.16) μg/L and 0.808 (0.111) respectively (p < 0.05). In subjects with asthma atopy was significantly associated to urine Se 0.24 (0.73) (β (SE)) (p < 0.05). Subjects with BHR had the same Se status as subjects with no respiratory symptoms and heavy smokers had a lower concentration of Se in serum 73.80 (9.56) μg/L than non-smokers 78.16 (10.74) μg/L (p < 0.05), Se status was associated to asthma and smoking. Measuring Se in urine might add further information to possible relations between Se status, atopy and asthma.
AB - To examine the associations between selenium (Se) status, asthma, bronchial hyperresponsiveness (BHR), and atopy in 154 male subjects (72 with mild asthma, 41 with BHR and 41 with no respiratory symptoms) aged 18 (range 17-22) years. Each subject underwent a medical interview and FEV1 and FVC were recorded. Histamine bronchial reactivity (Yan method) was measured, skin prick test (inhalant allergens) was performed and Se in urine and serum was analysed (AOAC modified fluometric method). Se in serum 74.04 (10.58) μg/L (mean (SD)) was lower in subjects with asthma and the logarithm of the ratio of Se in serum (μg/L) and urine standardised to creatinine excretion (ng/mg creatinine) 0.748 (0.096) (mean (SD)) was lower in subjects with asthma and atopy compared to subjects with no allergic symptoms 77.79 (10.16) μg/L and 0.808 (0.111) respectively (p < 0.05). In subjects with asthma atopy was significantly associated to urine Se 0.24 (0.73) (β (SE)) (p < 0.05). Subjects with BHR had the same Se status as subjects with no respiratory symptoms and heavy smokers had a lower concentration of Se in serum 73.80 (9.56) μg/L than non-smokers 78.16 (10.74) μg/L (p < 0.05), Se status was associated to asthma and smoking. Measuring Se in urine might add further information to possible relations between Se status, atopy and asthma.
KW - Asthma
KW - Atopy
KW - Bronchial hyperresponsiveness
KW - Selenium
KW - Smoking
KW - Turnover
UR - http://www.scopus.com/inward/record.url?scp=0036321427&partnerID=8YFLogxK
U2 - 10.1016/S0946-672X(02)80039-6
DO - 10.1016/S0946-672X(02)80039-6
M3 - Journal article
C2 - 12195727
AN - SCOPUS:0036321427
SN - 0946-672X
VL - 16
SP - 123
EP - 127
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
IS - 2
ER -