TY - JOUR
T1 - Self-assembled nanoparticles based on cyclodextrin-modified pullulan
T2 - Synthesis, and structural characterization using SAXS
AU - Stensgaard Diget, Jakob
AU - Lund, Reidar
AU - Nyström, Bo
AU - Wintgens, Véronique
AU - Amiel, Catherine
AU - Wimmer, Reinhard
AU - Terndrup Nielsen, Thorbjørn
PY - 2019/6/1
Y1 - 2019/6/1
N2 -
Synthesis of novel host-guest functionalized polymers is presented along with structural characterization using small-angle X-ray scattering (SAXS) of the resulting nanoparticles. Mono-6-deoxy-mono-6-azidoβCD (N
3
βCD) was grafted onto alkyne-functionalized pullulan via the “click” reaction copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) and an adamantane-modified dextran was prepared via the same strategy. Characterization of the polymers was carried out using nuclear magnetic resonance (NMR) spectroscopy, gel filtration chromatography (GFC), isothermal titration calorimetry (ITC) and SAXS. Nanoparticles were created via host-guest interactions between the well-defined βCD-pullulans and adamantane-modified dextran. Characterization was carried out using dynamic light scattering (DLS) and SAXS, which revealed spherical particles in the sub-100 nm range. The studies shed light on the importance of molecular structure and host-guest ratio on crucial properties such as particle size, size distribution, porosity and stability towards aggregation.
AB -
Synthesis of novel host-guest functionalized polymers is presented along with structural characterization using small-angle X-ray scattering (SAXS) of the resulting nanoparticles. Mono-6-deoxy-mono-6-azidoβCD (N
3
βCD) was grafted onto alkyne-functionalized pullulan via the “click” reaction copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) and an adamantane-modified dextran was prepared via the same strategy. Characterization of the polymers was carried out using nuclear magnetic resonance (NMR) spectroscopy, gel filtration chromatography (GFC), isothermal titration calorimetry (ITC) and SAXS. Nanoparticles were created via host-guest interactions between the well-defined βCD-pullulans and adamantane-modified dextran. Characterization was carried out using dynamic light scattering (DLS) and SAXS, which revealed spherical particles in the sub-100 nm range. The studies shed light on the importance of molecular structure and host-guest ratio on crucial properties such as particle size, size distribution, porosity and stability towards aggregation.
KW - Host-guest chemistry
KW - Pullulan
KW - Self-assembly
KW - Small-angle X-ray scattering (SAXS)
KW - β-Cyclodextrin (βCD)
KW - “Click” chemistry
UR - http://www.scopus.com/inward/record.url?scp=85062734854&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.01.106
DO - 10.1016/j.carbpol.2019.01.106
M3 - Journal article
AN - SCOPUS:85062734854
SN - 0144-8617
VL - 213
SP - 403
EP - 410
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -