TY - JOUR
T1 - Self-assembly of cyclodextrins
T2 - Formation of cyclodextrin polymer based nanoparticles
AU - Fülöp, Z.
AU - Kurkov, S.V.
AU - Nielsen, T.T.
AU - Larsen, Kim Lambertsen
AU - Loftsson, T.
PY - 2012/5/1
Y1 - 2012/5/1
N2 - The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.
AB - The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.
UR - http://www.scopus.com/inward/record.url?scp=84862850770&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:84862850770
SN - 1773-2247
VL - 22
SP - 215
EP - 221
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 3
ER -