Self-assembly of cyclodextrins: Formation of cyclodextrin polymer based nanoparticles

Z. Fülöp, S.V. Kurkov, T.T. Nielsen, Kim Lambertsen Larsen, T. Loftsson

Research output: Contribution to journalJournal articleResearchpeer-review

27 Citations (Scopus)


The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.
Original languageEnglish
JournalJournal of Drug Delivery Science and Technology
Issue number3
Pages (from-to)215-221
Number of pages7
Publication statusPublished - 1 May 2012


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