TY - JOUR
T1 - Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study
AU - Arthur, Rhonda
AU - Møller, Henrik
AU - Garmo, Hans
AU - Häggström, Christel
AU - Holmberg, Lars
AU - Stattin, Pär
AU - Malmström, Håkan
AU - Lambe, Mats
AU - Hammar, Niklas
AU - Walldius, Göran
AU - Robinson, David
AU - Jungner, Ingmar
AU - Van Hemelrijck, Mieke
PY - 2019/2
Y1 - 2019/2
N2 - PURPOSE: Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death.METHODS: From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regression models were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers.RESULTS: Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02-1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death.CONCLUSION: Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.
AB - PURPOSE: Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death.METHODS: From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regression models were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers.RESULTS: Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02-1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death.CONCLUSION: Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.
KW - Aged
KW - Blood Glucose/analysis
KW - Cholesterol/blood
KW - Cohort Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Proportional Hazards Models
KW - Prostatic Neoplasms/blood
KW - Sweden/epidemiology
KW - Triglycerides/blood
U2 - 10.1007/s10552-018-1093-1
DO - 10.1007/s10552-018-1093-1
M3 - Journal article
C2 - 30421156
SN - 0957-5243
VL - 30
SP - 195
EP - 206
JO - Cancer Causes & Control
JF - Cancer Causes & Control
IS - 2
ER -