Severe Peripheral Neuropathy From Treatment With Arsenic Trioxide in a Patient Suffering From Acute Promyelocytic Leukemia

Soren Niemi Helso; Anne Stidsholt Roug; Morten Mork; Eva Futtrup Maksten; Marianne Tang Severinsen

doi:10.14740/jh617

Severe Peripheral Neuropathy From Treatment With Arsenic Trioxide in a Patient Suffering From Acute Promyelocytic Leukemia

Soren Niemi Helso, Anne Stidsholt Roug, Morten Mork, Eva Futtrup Maksten, Marianne Tang Severinsen

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Abstract

Treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is standard treatment for patients suffering from acute promyelocytic leukemia (APL). Peripheral neuropathy is a common sign of arsenic poisoning but reports of peripheral neuropathy from patients treated with ATO for APL are limited. We here present a case of a woman treated with standard regimes of ATRA-ATO for APL, who subsequently developed severe peripheral neuropathy from ATO poisoning.

Original language	English
Journal	Journal of Hematology
Volume	9
Issue number	3
Pages (from-to)	89-92
Number of pages	4
ISSN	1927-1212
DOIs	https://doi.org/10.14740/jh617
Publication status	Published - Sept 2020

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10.14740/jh617Licence: CC BY-NC 4.0

Helsø et al (2020) Severe Peripheral Neuropathy From Treatment With Arsenic TrioxideFinal published version, 367 KBLicence: CC BY-NC 4.0

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abstract = "Treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is standard treatment for patients suffering from acute promyelocytic leukemia (APL). Peripheral neuropathy is a common sign of arsenic poisoning but reports of peripheral neuropathy from patients treated with ATO for APL are limited. We here present a case of a woman treated with standard regimes of ATRA-ATO for APL, who subsequently developed severe peripheral neuropathy from ATO poisoning.",

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AU - Mork, Morten

AU - Maksten, Eva Futtrup

AU - Severinsen, Marianne Tang

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N2 - Treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is standard treatment for patients suffering from acute promyelocytic leukemia (APL). Peripheral neuropathy is a common sign of arsenic poisoning but reports of peripheral neuropathy from patients treated with ATO for APL are limited. We here present a case of a woman treated with standard regimes of ATRA-ATO for APL, who subsequently developed severe peripheral neuropathy from ATO poisoning.

AB - Treatment with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is standard treatment for patients suffering from acute promyelocytic leukemia (APL). Peripheral neuropathy is a common sign of arsenic poisoning but reports of peripheral neuropathy from patients treated with ATO for APL are limited. We here present a case of a woman treated with standard regimes of ATRA-ATO for APL, who subsequently developed severe peripheral neuropathy from ATO poisoning.

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JO - Journal of Hematology

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Severe Peripheral Neuropathy From Treatment With Arsenic Trioxide in a Patient Suffering From Acute Promyelocytic Leukemia

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