Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS

Ali Asghar Zarei; Armita Faghani Jadidi; Romulus Lontis; Winnie Jensen

doi:10.1109/TBME.2021.3051307

Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS

Ali Asghar Zarei^*
, Armita Faghani Jadidi
, Romulus Lontis
, Winnie Jensen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

421 Downloads (Pure)

Abstract

Transcutaneous electrical nerve stimulation (TENS) has been reported to alleviate pain in chronic pain patients. Currently, there is limited knowledge how TENS affects can cause cortical neuromodulation and lead to modulation of non-painful and painful sensations. Our aim was therefore to investigate the effect of conventional, high-frequency TENS on cortical activation and perceived sensations in healthy subjects. We recorded somatosensory evoked potentials (SEPs) and perceived sensations following high-frequency TENS (100 Hz) in 40 healthy subjects (sham and intervention group). The effect of TENS was examined up to an hour after the intervention phase, and results revealed significant cortical inhibition. We found that the magnitude of N100, P200 waves, and theta and alpha band power was significantly suppressed following the TENS intervention. These changes were associated with a simultaneous reduction in the perceived intensity and the size of the area where the sensation was felt. Although phantom limb pain relief previously has been associated with an inhibition of cortical activity, the efficacy of the present TENS intervention to induce such cortical inhibition and cause pain relief should be verified in a future clinical trial.

Original language	English
Article number	9321509
Journal	I E E E Transactions on Biomedical Engineering
Volume	68
Issue number	7
Pages (from-to)	2261-2269
Number of pages	9
ISSN	0018-9294
DOIs	https://doi.org/10.1109/TBME.2021.3051307
Publication status	Published - Jul 2021

Bibliographical note

This project has received funding from the European Union’s Horizon 2020
research and innovation programmed under the Marie Skłodowska-Curie grant
agreement No 754465 and the Center for Neuroplasticity and Pain (CNAP),
which is supported by the Danish National Research Foundation (DNRF121).

Keywords

Band-pass filters
Electrical stimulation
Electrodes
Electroencephalography
Neuroplasticity
Pain
Phantoms
Sensory evoked potentials
Sensory feedback
TENS

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10.1109/TBME.2021.3051307

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Cite this

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title = "Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS",

abstract = "Transcutaneous electrical nerve stimulation (TENS) has been reported to alleviate pain in chronic pain patients. Currently, there is limited knowledge how TENS affects can cause cortical neuromodulation and lead to modulation of non-painful and painful sensations. Our aim was therefore to investigate the effect of conventional, high-frequency TENS on cortical activation and perceived sensations in healthy subjects. We recorded somatosensory evoked potentials (SEPs) and perceived sensations following high-frequency TENS (100 Hz) in 40 healthy subjects (sham and intervention group). The effect of TENS was examined up to an hour after the intervention phase, and results revealed significant cortical inhibition. We found that the magnitude of N100, P200 waves, and theta and alpha band power was significantly suppressed following the TENS intervention. These changes were associated with a simultaneous reduction in the perceived intensity and the size of the area where the sensation was felt. Although phantom limb pain relief previously has been associated with an inhibition of cortical activity, the efficacy of the present TENS intervention to induce such cortical inhibition and cause pain relief should be verified in a future clinical trial.",

keywords = "Band-pass filters, Electrical stimulation, Electrodes, Electroencephalography, Neuroplasticity, Pain, Phantoms, Sensory evoked potentials, Sensory feedback, TENS",

author = "Zarei, \{Ali Asghar\} and Jadidi, \{Armita Faghani\} and Romulus Lontis and Winnie Jensen",

note = "This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programmed under the Marie Sk{\l}odowska-Curie grant agreement No 754465 and the Center for Neuroplasticity and Pain (CNAP), which is supported by the Danish National Research Foundation (DNRF121).",

year = "2021",

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doi = "10.1109/TBME.2021.3051307",

language = "English",

volume = "68",

pages = "2261--2269",

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}

Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS. / Zarei, Ali Asghar; Jadidi, Armita Faghani; Lontis, Romulus et al.
In: I E E E Transactions on Biomedical Engineering, Vol. 68, No. 7, 9321509, 07.2021, p. 2261-2269.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS

AU - Zarei, Ali Asghar

AU - Jadidi, Armita Faghani

AU - Lontis, Romulus

AU - Jensen, Winnie

N1 - This project has received funding from the European Union’s Horizon 2020 research and innovation programmed under the Marie Skłodowska-Curie grant agreement No 754465 and the Center for Neuroplasticity and Pain (CNAP), which is supported by the Danish National Research Foundation (DNRF121).

PY - 2021/7

Y1 - 2021/7

N2 - Transcutaneous electrical nerve stimulation (TENS) has been reported to alleviate pain in chronic pain patients. Currently, there is limited knowledge how TENS affects can cause cortical neuromodulation and lead to modulation of non-painful and painful sensations. Our aim was therefore to investigate the effect of conventional, high-frequency TENS on cortical activation and perceived sensations in healthy subjects. We recorded somatosensory evoked potentials (SEPs) and perceived sensations following high-frequency TENS (100 Hz) in 40 healthy subjects (sham and intervention group). The effect of TENS was examined up to an hour after the intervention phase, and results revealed significant cortical inhibition. We found that the magnitude of N100, P200 waves, and theta and alpha band power was significantly suppressed following the TENS intervention. These changes were associated with a simultaneous reduction in the perceived intensity and the size of the area where the sensation was felt. Although phantom limb pain relief previously has been associated with an inhibition of cortical activity, the efficacy of the present TENS intervention to induce such cortical inhibition and cause pain relief should be verified in a future clinical trial.

AB - Transcutaneous electrical nerve stimulation (TENS) has been reported to alleviate pain in chronic pain patients. Currently, there is limited knowledge how TENS affects can cause cortical neuromodulation and lead to modulation of non-painful and painful sensations. Our aim was therefore to investigate the effect of conventional, high-frequency TENS on cortical activation and perceived sensations in healthy subjects. We recorded somatosensory evoked potentials (SEPs) and perceived sensations following high-frequency TENS (100 Hz) in 40 healthy subjects (sham and intervention group). The effect of TENS was examined up to an hour after the intervention phase, and results revealed significant cortical inhibition. We found that the magnitude of N100, P200 waves, and theta and alpha band power was significantly suppressed following the TENS intervention. These changes were associated with a simultaneous reduction in the perceived intensity and the size of the area where the sensation was felt. Although phantom limb pain relief previously has been associated with an inhibition of cortical activity, the efficacy of the present TENS intervention to induce such cortical inhibition and cause pain relief should be verified in a future clinical trial.

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KW - Electrodes

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KW - Neuroplasticity

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KW - Phantoms

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JO - I E E E Transactions on Biomedical Engineering

JF - I E E E Transactions on Biomedical Engineering

IS - 7

M1 - 9321509

ER -

Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS

Abstract

Bibliographical note

Keywords

Access to Document

AUB Link

Other files and links

Fingerprint

Phantom Limb Pain - Neural Mechanisms And Innovative Treatments

Towards Understanding the Neurobiological Effects of Modulated Tens

Cite this

Short-term Suppression of Somatosensory Evoked Potentials and Perceived Sensations in Healthy Subjects Following TENS

Abstract

Bibliographical note

Keywords

Access to Document

AUB Link

Other files and links

Fingerprint

Projects

Phantom Limb Pain - Neural Mechanisms And Innovative Treatments

Research output

Towards Understanding the Neurobiological Effects of Modulated Tens

Cite this