Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature

Ellen Taaning; Lise Jensen; Kim Varming

doi:10.1111/j.1651-2227.2012.02715.x

Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature

Ellen Taaning, Lise Jensen, Kim Varming

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia due to maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding due to maternal anti-HPA-3a alloantibodies and mild neutropenia due to maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion: This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

Original language	English
Journal	Acta Paediatrica
Volume	101
Pages (from-to)	896-9
Number of pages	4
ISSN	0803-5253
DOIs	https://doi.org/10.1111/j.1651-2227.2012.02715.x
Publication status	Published - 2012
Externally published	Yes

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title = "Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature",

abstract = "Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia due to maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding due to maternal anti-HPA-3a alloantibodies and mild neutropenia due to maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion: This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. {\textcopyright} 2012 The Author(s)/Acta Paediatrica {\textcopyright} 2012 Foundation Acta Paediatrica.",

author = "Ellen Taaning and Lise Jensen and Kim Varming",

note = "{\textcopyright} 2012 The Author(s)/Acta Paediatrica {\textcopyright} 2012 Foundation Acta Paediatrica.",

year = "2012",

doi = "10.1111/j.1651-2227.2012.02715.x",

language = "English",

volume = "101",

pages = "896--9",

journal = "Acta Paediatrica",

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TY - JOUR

T1 - Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies

T2 - a case study and review of the literature

AU - Taaning, Ellen

AU - Jensen, Lise

AU - Varming, Kim

PY - 2012

Y1 - 2012

N2 - Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia due to maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding due to maternal anti-HPA-3a alloantibodies and mild neutropenia due to maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion: This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

AB - Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia due to maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding due to maternal anti-HPA-3a alloantibodies and mild neutropenia due to maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion: This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

U2 - 10.1111/j.1651-2227.2012.02715.x

DO - 10.1111/j.1651-2227.2012.02715.x

M3 - Journal article

SN - 0803-5253

VL - 101

SP - 896

EP - 899

JO - Acta Paediatrica

JF - Acta Paediatrica

ER -

Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature

Abstract

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