Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study

Tarec Christoffer El-Galaly; Marianne T Severinsen; Kim Overvad; Rudi Steffensen; Anders Krogh Vistisen; Anne Tjønneland; Søren R Kristensen

doi:10.1111/bjh.12132

Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study

Tarec Christoffer El-Galaly, Marianne T Severinsen, Kim Overvad, Rudi Steffensen, Anders Krogh Vistisen, Anne Tjønneland, Søren R Kristensen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.

Original language	English
Journal	British Journal of Haematology
Volume	160
Issue number	6
Pages (from-to)	838-841
Number of pages	4
ISSN	0007-1048
DOIs	https://doi.org/10.1111/bjh.12132
Publication status	Published - Mar 2013

Keywords

Antithrombin III
Cell Adhesion Molecules
Cohort Studies
Denmark
Factor XII
Fibrin Fibrinogen Degradation Products
Genetic Predisposition to Disease
Humans
Platelet Membrane Glycoproteins
Polymorphism, Single Nucleotide
Receptors, Cell Surface
Risk Factors
Venous Thrombosis

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title = "Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study",

abstract = "A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.",

keywords = "Antithrombin III, Cell Adhesion Molecules, Cohort Studies, Denmark, Factor XII, Fibrin Fibrinogen Degradation Products, Genetic Predisposition to Disease, Humans, Platelet Membrane Glycoproteins, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Risk Factors, Venous Thrombosis",

author = "El-Galaly, {Tarec Christoffer} and Severinsen, {Marianne T} and Kim Overvad and Rudi Steffensen and Vistisen, {Anders Krogh} and Anne Tj{\o}nneland and Kristensen, {S{\o}ren R}",

note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",

year = "2013",

month = mar,

doi = "10.1111/bjh.12132",

language = "English",

volume = "160",

pages = "838--841",

journal = "British Journal of Haematology",

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TY - JOUR

T1 - Single nucleotide polymorphisms and the risk of venous thrombosis

T2 - results from a Danish case-cohort study

AU - El-Galaly, Tarec Christoffer

AU - Severinsen, Marianne T

AU - Overvad, Kim

AU - Steffensen, Rudi

AU - Vistisen, Anders Krogh

AU - Tjønneland, Anne

AU - Kristensen, Søren R

PY - 2013/3

Y1 - 2013/3

N2 - A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.

AB - A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.

KW - Antithrombin III

KW - Cell Adhesion Molecules

KW - Cohort Studies

KW - Denmark

KW - Factor XII

KW - Fibrin Fibrinogen Degradation Products

KW - Genetic Predisposition to Disease

KW - Humans

KW - Platelet Membrane Glycoproteins

KW - Polymorphism, Single Nucleotide

KW - Receptors, Cell Surface

KW - Risk Factors

KW - Venous Thrombosis

U2 - 10.1111/bjh.12132

DO - 10.1111/bjh.12132

M3 - Journal article

C2 - 23150947

SN - 0007-1048

VL - 160

SP - 838

EP - 841

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study

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Keywords

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