Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

Andrew James Thomas Stevenson, Svend Sparre Geertsen, Jens Bo Nielsen, Natalie Mrachacz-Kersting

Research output: Contribution to book/anthology/report/conference proceedingArticle in proceedingResearchpeer-review

Abstract

In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.
Original languageEnglish
Title of host publicationConverging Clinical and Engineering Research on Neurorehabilitation II : Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain
EditorsJaime Ibáñez, José González-Vargas, José María Azorín, Metin Akay, José Luis Pons
PublisherSpringer
Publication date2017
Pages1031-1036
ISBN (Print)978-3-319-46668-2
ISBN (Electronic)978-3-319-46669-9
DOIs
Publication statusPublished - 2017
EventInternational Conference on NeuroRehabilitation, ICNR - Segovia, Spain
Duration: 18 Oct 201621 Oct 2016
Conference number: 3

Conference

ConferenceInternational Conference on NeuroRehabilitation, ICNR
Number3
CountrySpain
CitySegovia
Period18/10/201621/10/2016
SeriesBiosystems and Biorobotics
Number15
ISSN2195-3562

Fingerprint

Motor Neurons
Walking
Tibial Nerve
Reflex
H-Reflex
Peroneal Nerve
Electromyography
Interneurons
Skeletal Muscle
Inhibition (Psychology)
Renshaw Cells

Cite this

Stevenson, A. J. T., Geertsen, S. S., Nielsen, J. B., & Mrachacz-Kersting, N. (2017). Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. In J. Ibáñez, J. González-Vargas, J. M. Azorín, M. Akay, & J. L. Pons (Eds.), Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain (pp. 1031-1036). Springer. Biosystems and Biorobotics, No. 15 https://doi.org/10.1007/978-3-319-46669-9_167
Stevenson, Andrew James Thomas ; Geertsen, Svend Sparre ; Nielsen, Jens Bo ; Mrachacz-Kersting, Natalie. / Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. editor / Jaime Ibáñez ; José González-Vargas ; José María Azorín ; Metin Akay ; José Luis Pons. Springer, 2017. pp. 1031-1036 (Biosystems and Biorobotics; No. 15).
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abstract = "In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.",
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Stevenson, AJT, Geertsen, SS, Nielsen, JB & Mrachacz-Kersting, N 2017, Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. in J Ibáñez, J González-Vargas, JM Azorín, M Akay & JL Pons (eds), Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. Springer, Biosystems and Biorobotics, no. 15, pp. 1031-1036, Segovia, Spain, 18/10/2016. https://doi.org/10.1007/978-3-319-46669-9_167

Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. / Stevenson, Andrew James Thomas; Geertsen, Svend Sparre; Nielsen, Jens Bo; Mrachacz-Kersting, Natalie.

Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. ed. / Jaime Ibáñez; José González-Vargas; José María Azorín; Metin Akay; José Luis Pons. Springer, 2017. p. 1031-1036.

Research output: Contribution to book/anthology/report/conference proceedingArticle in proceedingResearchpeer-review

TY - GEN

T1 - Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

AU - Stevenson, Andrew James Thomas

AU - Geertsen, Svend Sparre

AU - Nielsen, Jens Bo

AU - Mrachacz-Kersting, Natalie

PY - 2017

Y1 - 2017

N2 - In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.

AB - In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.

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EP - 1036

BT - Converging Clinical and Engineering Research on Neurorehabilitation II

A2 - Ibáñez, Jaime

A2 - González-Vargas, José

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A2 - Akay, Metin

A2 - Pons, José Luis

PB - Springer

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Stevenson AJT, Geertsen SS, Nielsen JB, Mrachacz-Kersting N. Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. In Ibáñez J, González-Vargas J, Azorín JM, Akay M, Pons JL, editors, Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. Springer. 2017. p. 1031-1036. (Biosystems and Biorobotics; No. 15). https://doi.org/10.1007/978-3-319-46669-9_167