Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

Andrew James Thomas Stevenson; Svend Sparre Geertsen; Jens Bo Nielsen; Natalie Mrachacz-Kersting

doi:10.1007/978-3-319-46669-9_167

Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

Andrew James Thomas Stevenson, Svend Sparre Geertsen, Jens Bo Nielsen, Natalie Mrachacz-Kersting

Research output: Contribution to book/anthology/report/conference proceeding › Article in proceeding › Research › peer-review

Abstract

In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.

Original language	English
Title of host publication	Converging Clinical and Engineering Research on Neurorehabilitation II : Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain
Editors	Jaime Ibáñez, José González-Vargas, José María Azorín, Metin Akay, José Luis Pons
Publisher	Springer
Publication date	2017
Pages	1031-1036
ISBN (Print)	978-3-319-46668-2
ISBN (Electronic)	978-3-319-46669-9
DOIs	https://doi.org/10.1007/978-3-319-46669-9_167
Publication status	Published - 2017
Event	International Conference on NeuroRehabilitation, ICNR - Segovia, Spain Duration: 18 Oct 2016 → 21 Oct 2016 Conference number: 3

Conference

Conference	International Conference on NeuroRehabilitation, ICNR
Number	3
Country/Territory	Spain
City	Segovia
Period	18/10/2016 → 21/10/2016

Series	Biosystems and Biorobotics
Number	15
ISSN	2195-3562

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10.1007/978-3-319-46669-9_167

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Interlimb coordination during human walking
Gervasio, S. & Stevenson, A. J. T.
01/10/2010 → …
Project: Research

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Stevenson, A. J. T., Geertsen, S. S., Nielsen, J. B., & Mrachacz-Kersting, N. (2017). Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. In J. Ibáñez, J. González-Vargas, J. M. Azorín, M. Akay, & J. L. Pons (Eds.), Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain (pp. 1031-1036). Springer. https://doi.org/10.1007/978-3-319-46669-9_167

Stevenson, Andrew James Thomas ; Geertsen, Svend Sparre ; Nielsen, Jens Bo et al. / Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. editor / Jaime Ibáñez ; José González-Vargas ; José María Azorín ; Metin Akay ; José Luis Pons. Springer, 2017. pp. 1031-1036 (Biosystems and Biorobotics; No. 15).

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title = "Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking",

abstract = "In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.",

author = "Stevenson, {Andrew James Thomas} and Geertsen, {Svend Sparre} and Nielsen, {Jens Bo} and Natalie Mrachacz-Kersting",

year = "2017",

doi = "10.1007/978-3-319-46669-9_167",

language = "English",

isbn = "978-3-319-46668-2",

series = "Biosystems and Biorobotics",

publisher = "Springer",

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booktitle = "Converging Clinical and Engineering Research on Neurorehabilitation II",

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note = "International Conference on NeuroRehabilitation, ICNR ; Conference date: 18-10-2016 Through 21-10-2016",

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Stevenson, AJT, Geertsen, SS, Nielsen, JB & Mrachacz-Kersting, N 2017, Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. in J Ibáñez, J González-Vargas, JM Azorín, M Akay & JL Pons (eds), Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. Springer, Biosystems and Biorobotics, no. 15, pp. 1031-1036, International Conference on NeuroRehabilitation, ICNR, Segovia, Spain, 18/10/2016. https://doi.org/10.1007/978-3-319-46669-9_167

Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. / Stevenson, Andrew James Thomas; Geertsen, Svend Sparre; Nielsen, Jens Bo et al.
Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. ed. / Jaime Ibáñez; José González-Vargas; José María Azorín; Metin Akay; José Luis Pons. Springer, 2017. p. 1031-1036 (Biosystems and Biorobotics; No. 15).

Research output: Contribution to book/anthology/report/conference proceeding › Article in proceeding › Research › peer-review

TY - GEN

T1 - Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

AU - Stevenson, Andrew James Thomas

AU - Geertsen, Svend Sparre

AU - Nielsen, Jens Bo

AU - Mrachacz-Kersting, Natalie

N1 - Conference code: 3

PY - 2017

Y1 - 2017

N2 - In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.

AB - In humans, short-latency crossed spinal inhibitory reflexes are elicited in the contralateral soleus (cSOL) muscle following stimulation of the ipsilateral posterior tibial nerve (iPTN). To date, the spinal interneurons mediating the cSOL inhibition are unknown. This study investigated whether the Ia inhibitory interneurons in the disynaptic reciprocal inhibition pathway mediate the short-latency cSOL inhibition. Following combined stimulation of the iPTN and the contralateral common peroneal nerve (cCPN), we quantified the spatial facilitation of the ongoing electromyography (EMG; Experiment 1) or the test H-reflex (Experiment 2) in the cSOL during walking. There was a significant increase in the cSOL inhibition when the two stimuli were elicited in combination compared to that expected from the algebraic sum of the two if elicited separately. It is therefore likely that the Ia inhibitory interneurons in the disynaptic reciprocal inhibitory pathway contribute to the short-latency cSOL inhibitory reflex.

U2 - 10.1007/978-3-319-46669-9_167

DO - 10.1007/978-3-319-46669-9_167

M3 - Article in proceeding

SN - 978-3-319-46668-2

T3 - Biosystems and Biorobotics

SP - 1031

EP - 1036

BT - Converging Clinical and Engineering Research on Neurorehabilitation II

A2 - Ibáñez, Jaime

A2 - González-Vargas, José

A2 - Azorín, José María

A2 - Akay, Metin

A2 - Pons, José Luis

PB - Springer

T2 - International Conference on NeuroRehabilitation, ICNR

Y2 - 18 October 2016 through 21 October 2016

ER -

Stevenson AJT, Geertsen SS, Nielsen JB, Mrachacz-Kersting N. Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking. In Ibáñez J, González-Vargas J, Azorín JM, Akay M, Pons JL, editors, Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation, ICNR2016, 18-21 October 2016, Segovia, Spain. Springer. 2017. p. 1031-1036. (Biosystems and Biorobotics; No. 15). doi: 10.1007/978-3-319-46669-9_167

Spatial facilitation of reciprocal inhibition and crossed inhibitory responses to soleus motoneurons during walking

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Interlimb coordination during human walking

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